This high percentage suggests a clonotypic recognition, where several B-1a clones are involved, which can be explained by the presence of a regulatory idiotope
on P3 variable region .
The presence of a crossreactive idiotope
on the heavy chains of many monoclonal antibodies against 3-FL suggested that their variable region structures might be very similar.
The network is activated when an antibody (cell receptor) recognises antigen and the network is suppressed when an antibody recognises an idiotope
. The immune network theory suggests that the receptor molecules contained in the surface of the immune cells present idiotopes
, and these idiotopes
are displayed in and/or around the same portions of the receptors that recognize non-self antigens.
Methods are provided for inhibiting the differentiation of adipocyte precursor cells, and for treating or preventing obesity, which comprise administering an effective amount of a composition capable of binding to and activating the EGF receptor, preferably epidermal EGF or a functional derivative thereof, TGF Alpha , an antibody specific for the EGF receptor or an anti-idiotypic antibody specific for an idiotope
on an antibody specific for EGF.
Each helps direct the critic along the contour of a writer's "paysage personnel." Richard's objective is to pass beneath the writer's stylistic tuff to its core and to emerge having experienced a textual "coherence interne." He would have thus comprehended, without sacrificing complexity, the writer's idiotope
. Further, Richard states that his purpose is to present a classification of the material (tissu) of a given writer's works.
Rodriguez, "A monoclonal antibody against NeuGc-containing gangliosides contains a regulatory idiotope
involved in the interaction with B and T cells," Molecular Immunology, vol.
We speculate that the patient's antibody binds to an idiotope
on one of the antibodies used in the AxSYM assay and sterically blocks the binding of TSH to that antibody.
Antiidiotypic antibody, an antibody that binds to an idiotope
. In a practical sense, it is not be possible to distinguish an idiotope
from a paratope because the binding sites are equivalent.
Artificial immune network model is based on the theory of immune network, which states that the immune cells act as a mutually reinforcing network constructed by the matching between paratopes and idiotopes