Idiotypes - definition of Idiotypes by The Free Dictionary
idiotype (redirected from Idiotypes)
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The complete set of idiotopes contained within the variable region of a particular immunoglobulin molecule and making up the molecule's antigen binding site.
id′i·o·typ′ic (-tĭp′ĭk) adj.
id′i·o·ty′py (-tī′pē) n.
the unique part of an antibody
References in periodicals archive
It has a complete immune system with a diverse antibody repertoire and generates antibodies with human idiotypes
as effectively as wild-type animals make rat antibodies.
Traditional local genotypes appear to make idiotypes
in ours conditions culture .
This approach is based on the immune network theory of Jerne (1974), who proposed that the immune system is a network of interacting idiotypes
that is involved in the regulation of immune responses.
It has a complete immune system with a diverse antibody repertoire and is genetically engineered to produce antibodies with human idiotypes
Specific antibodies have repeated (cross-reacting, or general) idiotypes
and so-called private idiotypes
are unique amino acid sequences in the variable regions of antibodies.
located on light and heavy chains of human myeloma proteins characterized by monoclonal antibodies.