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Related to Il-4: IL-5, IL-2, IL-13


Any of various small proteins that are produced by a variety of cell types, especially T cells and other white blood cells, and that regulate many aspects of inflammation and the immune response, including stimulating the production of white blood cells and platelets.


(Biochemistry) a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer


(ˈɪn tərˌlu kɪn)
any of a family of small proteins that participate in the body's defense system, esp. by promoting the growth and activation of white blood cells.
[1979; inter- + leuk (ocyte) + -in1; so called because such proteins act as agents of communication between different populations of leukocytes]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.interleukin - any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
lymphokine - a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages)
References in periodicals archive ?
Furthermore, in vitro we investigated mRNA expression for IL-22 and IL-22 BP, and IL 22 receptor after co-stimulation of peripheral blood mononuclear cells (PBMC) from individuals with asthma and normal controls with Th2 cytokines IL-4, IL-9, and GM-CSF in a time-dependent manner.
Whereas Th subset1(Th1) cells secrete interferon-gamma (IFN-gamma) in response to differentiation cues from IL12 and mediate cellular immunity, Th subset2 (Th2) cells secrete IL-4 upon differentiation in the presence of IL-4 and activate allergic and humoral responses.
Metal and transition metal ions also induced significant secretion of interleukin (IL)-4 and increased antigen-mediated IL-4 secretion in mast cells.
It appears that the IL-4 is somehow decreasing the production of new bone," says David B.
In laboratory experiments, the IL-4/13 Trap binds both IL-4 and IL-13 with high affinity.
Elevated levels of IL-4, IL-5, and IL-10 secretion by Th2 CD4+ cells, as well as suppressed levels of IL-2, and interferon (IFN-[Gamma]) secretion by Th1 CD4+ cells may enhance production of IgE, promote mast cell proliferation and maturation, augment airway hyperresponsiveness, and increase recruitment of eosinophils.
As with IL-7, IL-4 binds to its receptor's lone subunit.
This family includes Cytokine Traps for IL-1, IL-4, and IL-6, and a single Trap which blocks both IL-4 and IL-13.
While approximately one third of the patients exhibited side effects during or immediately following therapy, they are consistent with marked tumor cell death and the subsequent inflammatory response resulting from the IL-4 toxin therapy.