light chain

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light chain

n.
Either of the two smaller polypeptide chains in an immunoglobulin molecule, consisting of an antigen-binding portion with a variable amino acid sequence and a constant region that occurs in two different forms in humans.
References in periodicals archive ?
The urine dipstick is specific for albumin and will miss positively charged proteins in the urine, such as immunoglobulin light chains.
Detection of B-cell clonality by showcasing the restricted expression of one of the two immunoglobulin light chains (kappa or lambda) provides valuable molecular information for the diagnosis of NHLs.
Detection of B-cell clonality by demonstrating the restricted expression of one of the two immunoglobulin light chains (kappa or lambda) provides valuable molecular information for the diagnosis of NHLs.
In a case with a diagnosis that included MBL, one of the populations was negative for surface immunoglobulin light chains and positive for CD5, whereas the other population was monotypic for k light chains.
Outcome in systemic AL amyloidosis in relation to changes in concentration of circulating free immunoglobulin light chains following chemotherapy.
A subtype of myeloma is light chain myeloma, where only immunoglobulin light chains are expressed, and a serum free monoclonal light chain analysis can quantify the exact amount.
Immunoglobulin light chains [kappa] and [lambda] as well as three classical markers of inflammation were found to be significantly high in JIA patients who were in the active stage of disease when compared to data of healthy children and to JIA patients who were in remission (Table 1 and 2).
But the growing clinical acceptance of a serum free light chain assay has all but eliminated urine tests in identifying such plasma cell disorders as multiple myeloma (MM), smoldering myeloma, monoclonal gammopathy of undetermined significance (MGUS) and primary systemic amyloidosis (AL); and because the assay has proven to be more sensitive than IFE for detecting free or unbound immunoglobulin light chains when it is used in conjunction with SPEP, up to 99% of myelomas can be detected.
The kidney is one of the most common organs involved by amyloidosis, especially by AL amyloidosis, which contains immunoglobulin light chains produced by abnormal clonal plasma cells.
Our patient had primary systemic (AL) amyloidosis, which occurs when a monoclonal population of plasma cells generates excess amyloidogenic immunoglobulin light chains.
The amyloid deposits were composed of immunoglobulin light chains of the same types expressed by the neoplastic cells in all 3 cases.
Composition of amyloid in various types of amyloidosis * Type Subtype Composition of amyloid Localized Nodular Immunoglobulin light chains produced by cutaneous local plasma cell infiltration Lichen Keratinocyte tonofilaments Macular Keratinocyte tonofilaments Systemic Primary Immunoglobulin light chains resulting from plasma cell dyscrasia Secondary An apoprotein complex resulting from chronic inflammation; no cutaneous lesions are seen * From references 7, 8.

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