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Related to incretin: Sitagliptin


Any of several gastrointestinal hormones that bring about the release of insulin from the pancreas after carbohydrate ingestion and are essential in maintaining normal levels of glucose in the blood.

[Blend of increase and secretin.]
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DPP4 destroys the hormone incretin that stimulates insulin secretion in response to meals.
Observations that oral glucose provokes a greater insulin secretory response than the same amount of glucose injected into a vein, (1) coupled with isolation of an extract from the upper intestine that produces a fall in blood glucose, (2,3) led to recognition that the incretin system plays a role in glucose homeostasis.
New non-insulin treatments for type 2 diabetes mellitus include the use of incretin modulators.
The treatment is a once-daily inhibitor that selectively inhibits DPP-4 and increases the active incretin levels, which causes a glucose-dependent glucose-lowering effect.
Incretin hormones stimulate the release of insulin from the pancreas.
Dipeptidyl peptidase-4 inhibitors (DDP4s) result in prolonged active incretin levels, which results in regulation of glucose homeostasis by increasing insulin synthesis and release from beta cells.
And a very important element of incretin action is that they restore insulin release in patients with diabetes" and moderate appetite, he said.
A DPP-4 inhibitor enhances the insulin secretion based on the plasma glucose levels, and it controls the levels by selectively inhibiting DPP-4 activity that inactivates two hormones, the incretin hormones (gastrointestinal hormones that promote insulin secretion) that play important roles in adjusting blood glucose, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP)
They also secrete high amounts of insulin and C-peptide, making the cells an excellent research tool in the field of diabetes and for other beta cell-related studies, such as beta-cell function, screening of compounds that regulate insulin secretion, GSIS studies, incretin response, pancreatitis research, and transdifferentiation studies.
Keywords: Incretin therapy, Exenatide, Liraglutide, Exenatide QW.
The injectable incretin are there in market and these promise good glycemic control in diabetic patients, along with various other benefits.