Drucker's diabetes research has focused on a group of hormones called incretins
, which help the pancreas produce insulin to use the energy it receives from food.
The STELLUX[R] Chemi Glucagon ELISA is highly specific with 100% cross-reactivity to glucagon, and does not cross-react with other proglucagon peptides such as oxyntomodulin, glicentin and the incretins
glucagon-like peptide-1 and gastric inhibitory polypeptide.
The weekly dual glucose-dependent insulinotropic polypeptide, or GIP, and GLP-1 receptor agonist integrates the action of both incretins
into a single novel molecule, aiming to build upon the clinical benefits seen with a selective GLP-1 RA.
Key players are insulin, glucagon, amylin, incretins
, and even the bacterial population of the gut.
"One way that gastric bypass might work is that it alters the incretins
that drive insulin secretion and sensitivity," Dr.
Recent years have seen the development of drugs that increase plasma incretins
for treatment of type 2 diabetes mellitus (DM).
Egan, "The role of incretins
in glucose homeostasis and diabetes treatment," Pharmacological Reviews, vol.
Whilst the limited clinical experience with newer classes such as incretins
and SGLT2 inhibitors suggests that they may have a favourable risk/benefit ratio, there is an urgent need for larger randomized controlled trials of these drugs in the management of PTDM after heart transplantation.
Ohlsson, "Esophageal and gastric dysmotilities are associated with altered glucose homeostasis and plasma levels of incretins
and leptin," The Review of Diabetic Studies, vol.
are the superfamily of polypeptides released from intestinal cells in response to nutritional ingestion.
are a group of metabolic hormones that stimulate a decrease in blood glucose levels.
Jens Holst, MD (professor of medical physiology, University of Copenhagen, Copenhagen, Denmark), studies the effects of incretins
in type II diabetes.