Granisetron is an indazole
derivative, which is a more selective 5HT3 antagonist than ondansetron.
The synthetic compound hypoxic+ 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole
(YC-1) has superior anti-angiogenic and anti-tumor activities.
Guedes da Silva et al., "Tuning of redox potentials for the design of ruthenium anticancer drugs-an electrochemical study of [trans-RuCl4L (DM SO)]-and [trans-RuCl4L2]-complexes, where L = imidazole, 1,2,4-triazole, indazole
," Inorganic Chemistry, vol.
Doskocz et al., "On the interactions of indazole
derivative with nucleosides - toward modeling the cytotoxic activity mechanism," Computational and Theoretical Chemistry, vol.
2004) and produce a range of bioactive compounds including the indole derivative indazole-3-carbaldehyde (Indazole
) (Fotso Fondja Yao et al.
Derivatives of indazole
and other pyrazole-containing condensed systems are attracting attention because of their biological activity and the possibilities of further conversions.
derivatives are reported to exhibit antibacterial [1,2], antifungal [1.2], antiproliferative , antigiogenic , antiarrhythmic and analgesic  activities and antihypertensive properties , while quinazolines exhibit antitumor , antimicrobial  antitubercular , antiagonists , anticonvulsant  and analgesic activities.
(iii) Soluble guanylyl cyclase GC-S (synthesizes cGMP) (NO independent activator YC-1 [3-(5'-hydroxymethy1-2'-fury1)-1-benzyl indazole
, 10 [micro]umo1 [1.sup.-1]]) (Lee et al., 2011)
Effects of NG-nitro-L-arginine methyl ester, 7-nitro indazole
, and agmatine on pentylenetetrazol-induced discriminative stimulus in Long-Evans rats Prog Neuropsychopharmacol Biol Psychiatry 2002; 26:567-73.
The effect of 7-nttro indazole
on pentobatbital-induced sleep in mice.