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Related to Indazole: imidazole, benzimidazole


n.1.(Chem.) A bicyclic nitrogenous compound, C7H6N2, analogous to indole, having a benzene ring fused to a pyrazole ring; called also indazol and benzopyrazole. It can be produced from a diazo derivative of cinnamic acid.
Webster's Revised Unabridged Dictionary, published 1913 by G. & C. Merriam Co.
References in periodicals archive ?
The synthetic compound hypoxic+ 3-(5'-hydroxymethyl-2'-furyl)-1-benzyl indazole (YC-1) has superior anti-angiogenic and anti-tumor activities.
Guedes da Silva et al., "Tuning of redox potentials for the design of ruthenium anticancer drugs-an electrochemical study of [trans-RuCl4L (DM SO)]-and [trans-RuCl4L2]-complexes, where L = imidazole, 1,2,4-triazole, indazole," Inorganic Chemistry, vol.
Doskocz et al., "On the interactions of indazole derivative with nucleosides - toward modeling the cytotoxic activity mechanism," Computational and Theoretical Chemistry, vol.
2004) and produce a range of bioactive compounds including the indole derivative indazole-3-carbaldehyde (Indazole) (Fotso Fondja Yao et al.
Derivatives of indazole and other pyrazole-containing condensed systems are attracting attention because of their biological activity and the possibilities of further conversions.
Indazole derivatives are reported to exhibit antibacterial [1,2], antifungal [1.2], antiproliferative [3], antigiogenic [3], antiarrhythmic and analgesic [4] activities and antihypertensive properties [5], while quinazolines exhibit antitumor [6], antimicrobial [7] antitubercular [8], antiagonists [9], anticonvulsant [10] and analgesic[11] activities.
(iii) Soluble guanylyl cyclase GC-S (synthesizes cGMP) (NO independent activator YC-1 [3-(5'-hydroxymethy1-2'-fury1)-1-benzyl indazole, 10 [micro]umo1 [1.sup.-1]]) (Lee et al., 2011)
Effects of NG-nitro-L-arginine methyl ester, 7-nitro indazole, and agmatine on pentylenetetrazol-induced discriminative stimulus in Long-Evans rats Prog Neuropsychopharmacol Biol Psychiatry 2002; 26:567-73.