indole

(redirected from Indolyl)
Also found in: Medical, Encyclopedia.
Related to Indolyl: indole

in·dole

 (ĭn′dōl′)
n.
1. A white crystalline compound, C8H7N, obtained from coal tar or various plants and produced by the bacterial decomposition of tryptophan in the intestine. It is used in perfumes and as a reagent.
2. Any of various derivatives of this compound.

indole

(ˈɪndəʊl) or

indol

n
(Elements & Compounds) a white or yellowish crystalline heterocyclic compound extracted from coal tar and used in perfumery, medicine, and as a flavouring agent; 1-benzopyrrole. Formula: C8H7N
[C19: from ind(igo) + -ole1]

in•dole

(ˈɪn doʊl)

n.
a colorless to yellowish solid, C8H7N, that has a low melting point and a fecal odor, is obtained from coal tar or from animal feces, and is used in perfumery and as a reagent.
[1865–70]
References in periodicals archive ?
(20) After donating an electron to OH* melatonin becomes a free radical itself, the indolyl radical cation with very low reactivity, thereby being non toxic to cells.
Moreover, SA was used as a simple organocatalyst for the synthesis of diarylmethanones [52], [alpha]-aryl ketones [53], pyrrolidine derivatives [54], 2,3-dihydroquinazolin-4(1H)-ones [55], homoallylic alcohols [56] as well as 3,3'-bis(indolyl)methanes (BIMs) [57].
Shah, A Facile Synthesis of Novel Bis-(indolyl)-1, 3, 4-oxadiazoles as Potent Cytotoxic Agents, ChemMedChem., 7, 1915 (2012).
Covalent interaction between enzymes and immobilization supports takes place due to the presence of side chain amino acids like arginine, aspartic acid, histidine of enzymes and level of reactivity in view of functional groups like imidazole, indolyl, phenolic hydroxyl, etc.
Rao, "Indium(III) chloride catalyzed three-component coupling reaction: a novel synthesis of 2-substituted aryl(indolyl)kojic acid derivatives as potent antifungal and antibacterial agents," Bioorganic & Medicinal Chemistry Letters, vol.
As already mentioned, a number of studies have highlighted the capacity of AhR to respond to indolyl metabolites, including indoxyl-3-sulfate, 6-formylindolo[3,2b]carbazole, kyneurenine, kynurenic acid, tryptamine, indole-3-acetate, and dietary indoles (indole-3-carbinol and 3,3'-diindolylmethane from the Cruciferous vegetables), thus positioning the AhR as a candidate indole receptor [11, 15, 43, 44].
A mixture of substituted indolyl triazole 1a-c (0.01 mol) and substituted chalcones 2ai (0.01 mol) was powdered, mixed, and introduced to borosil sample crucible containing few drops of acetic acid.
Marzo et al., "Exploring bis(indolyl)methane moiety as an alternative and innovative CAP group in the design of histone deacetylase (HDAC) inhibitors," Bioorganic and Medicinal Chemistry Letters, vol.
The carbonyl group in 3-position of isatins readily makes isatins undergo electrophilic condensation reactions with indoles to produce 3,3-di(indolyl)indolin-2-ones, which also show excellent bioactivities [6-8].
In addition, the chemical modifications of indole and its deriva-tives have been and continue to be a research hotspot for synthetic organic chemists and medicinal chem-ists, especially directing 3-substituted indolyl moiety [2-5], serving as various precursors of antiviral [6], anticancer [7], antibacterial [8], anti-inflammatory [9] and cytotoxic drugs [10].