(INHA) is a glycoprotein hormone which has a role in regulating the synthesis and secretion of pituitary follicle-stimulating hormone.
Differential regulation of inhibin A
and inhibin B by luteinizing hormone, follicle-stimulating hormone, and stage of follicle development.
The control includes AFP, Free Estriol, hCG and Inhibin A
, making it ideal for laboratories performing triple or quadruple marker screening.
, inhibin B, follcle-stimulating hormone, luteinizing hormone, estradiol, and sex hormone-binding globulin levels in healthy infant girls.
Activin-A is a dimeric glycoprotein composed of two B subunits of inhibin A
. In goats, mRNAs for inhibin BA subunit and for activin receptors (ActRIIA, ActRIIB, ActRIA, ActRIB) have been demonstrated in primordial, primary, secondary and antral follicles (SILVA et al., 2004), but the level of mRNA for inhibin BA at different stages of development is still not known.
Of four markers studied, inhibin A
was the only one associated with the risk of stillbirth after adjustment for the other markers and risk factors known before pregnancy But elevated levels of this marker alone had a positive likelihood ratio of just 5.44.
Serum inhibin A
and inhibin B in healthy prepubertal, pubertal, and adolescent girls and adult women: relation to age, stage of puberty, menstrual cycle, follicle-stimulating hormone, luteinizing hormone, and estradiol levels.
Seventy-nine matched case-control sets of maternal serum samples (each Down syndrome case matched to 5 controls) from 11 through 13 completed weeks of gestation were taken and assayed for levels of free beta-hCG, total hCG, and inhibin A
. Distribution characteristics and correlations of the multiples of the median values were estimated in cases and controls.
Maternal serum screening for Down syndrome is commonly performed in the 2nd trimester using a fetoprotein (AFP), unconjugated estriol (uE3), human chorionic gonadotropin (hCG), and inhibin A
. Concentrations of each marker are combined with maternal age to calculate a patient-specific risk of fetal Down syndrome.
Dimeric inhibin A
, a fourth biochemical marker for second-trimester Down syndrome screening, became more widely available last month when a national commercial laboratory added the test to its traditional triple-marker screening test.
The ACTIVE Inhibin A
ELISA for in vitro diagnostic use is available as an aid in the diagnosis and monitoring of various hormonal reproductive disorders.