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Related to Inhibins: Activin B


A peptide hormone secreted by the follicular cells of the ovary and the Sertoli cells of the testis that inhibits secretion of follicle-stimulating hormone from the anterior pituitary.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biology) biology a peptide hormone, produced by both the ovary and the testis, that inhibits (and thus regulates) the production of FSH (follicle-stimulating hormone)
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ɪnˈhɪb ɪn)
a male hormone that acts on the pituitary gland to limit the secretion of FSH.
[1980–85; inhib (it) + -in1]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
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Inhibins are also involved in the regulation of folliculogenesis through autocrine and/or paracrine control [9], therefore, it has been predicted that immunoneutralization of endogenous inhibin would lead to an increase in pituitary FSH secretion which could promote ovarian hyperstimulation, resulting in an increased ovulation rate.
Inhibins are dimeric glycoproteins that have primarily been studied for their role in antagonism of activin-mediated release of follicle-stimulating hormone (FSH) from gonadotropes of the anterior pituitary (Cook et al., 2004).
Inhibin-A (INH-A) and inhibin-B (INH-B), which are the bioactive forms of inhibins in the [alpha]-subunit, are synthesized in the granulosa cells of the ovaries (18).
Transforming growth factor-[beta]s (TGF-[beta]s), activins, inhibins, bone morphogenetic proteins (BMPs), growth differentiation factors (GDFs), Lefty, Nodal, and anti-Mullerian hormone make up a large superfamily of secreted signaling proteins that play key roles in embryonic development and adult tissue homeostasis (Wu and Hill, 2009).
Activins are heterodimers (AYAAYB, activin AB) or two homodimers (AYAAYA, activin-A; AYBAYB, activin B) of the AY subunits of inhibin. Like inhibins, they were originally described as being gonadally produced regulators of pituitary hormone release, but they are currently known to have a broader range of effects (Phillips, 2005).
Comparison of preovulatory follicular concentrations of epidermal growth factor, insulin-like growth factor-I, and inhibins A and B in women undergoing assisted conception treatment with gonadotropin-releasing hormone (GnRH) agonists and GnRH antagonists.
Dimeric inhibins in girls from birth to adulthood: relationship with age, pubertal stage, FSH and oestradiol.
In the first part of this volume the basic concepts of transforming growth factor [Beta], or TGF[Beta], signaling in normal physiology and cancer pathobiology are described in 32 chapters, with topics that include TGF[Beta] availability, regulators of Smad activity by phosphorylation, activins and inhibins in cancer progression, and uterine sensitization associated Gene-1.
Other proposed methods include vaginal ultrasound to measure ovarian volume and number of antral follicles and assays for inhibins, but currently the test characteristics for these are inferior to less invasive and less costly methods.
Inhibins are glycoprotein hormones secreted by the ovaries in nonpregnant women and by the placenta.
During her time there, Gill conducted research - culminating in a PhD - into the group of hormones known as inhibins.
Among the other topics are activins and inhibins, agonists and antagonists of the TGF-BEta family ligands, regulation of the Smad pathway by signaling cross-talk, and BMP-based therapeutics and the BMP signaling pathways.