(redirected from Inositol 1,4,5-trisphosphate)
Also found in: Thesaurus, Medical, Encyclopedia.


 (ĭ-nō′sĭ-tôl′, -tōl′, ī-nō′-)
Any of nine isomeric alcohols, C6H12O6·2H2O, that are precursors to various signaling molecules.

[Greek īs, īn-, sinew; see wei- in Indo-European roots + -os(e) + -it(e) + -ol.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Chemistry) a cyclic alcohol, one isomer of which (i-inositol) is present in yeast and is a growth factor for some organisms; cyclohexanehexol. Formula: C6H12O6
[C19: from Greek in-, is sinew + -ose2 + -ite1 + -ol1]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ɪˈnoʊ sɪˌtɔl, -ˌtoʊl, aɪˈnoʊ-)

a compound, C6H12O6, occurring in animal tissue, plants, and many seeds, that functions as a growth factor.
[1890–95; inosite an earlier name (< Greek īn-, s. of is fiber, sinew + -ose2 + -ite1) + -ol1]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.inositol - an optically inactive alcohol that is a component of the vitamin B complex
B complex, B vitamin, B-complex vitamin, vitamin B, vitamin B complex, B - originally thought to be a single vitamin but now separated into several B vitamins
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Stimulation of CaSR activates phospholipase C, resulting in the production of diacylglycerol and inositol 1,4,5-trisphosphate, the latter of which releases [Ca.sup.2+] from the endoplasmic reticulum.
Stimulation of GPCRs via G[alpha] leads to downstream activation of Phospholipase C isoform [beta]2 (PLC[beta]2), which in turn produces downstream inositol 1,4,5-trisphosphate (IP3).
Deneubourg et al., "A specific increase in inositol 1,4,5-trisphosphate 3-kinase B expression upon differentiation of human embryonic stem cells," Cellular Signalling, vol.
The mechanisms underlying this beneficial effect are unknown, although it has been proposed that the [Ca.sup.2+] released from RyRs provides an increased pool of [Ca.sup.2+] for the positive feedback on inositol 1,4,5-trisphosphate receptors [29].
OXTR: oxytocin receptor; VDCC: voltage-dependent calcium channels; [PIP.sub.2]: phosphatidylinositol biphosphate; [IP.sub.3]: inositol 1,4,5-trisphosphate; DAG: diacylglycerol.
It has been hypothesized that GJIC might be involved in the onset of the differentiation process, to coordinate the myoblasts that are committed to differentiate, thus promoting their alignment and fusion, and, consequently, the intercellular diffusion of critical signaling molecules (i.e., [Ca.sup.2+], inositol 1,4,5-trisphosphate, and adenosine 5-'triphosphate) [21, 24, 25].
* Putative inositol 1,4,5-trisphosphate binding protein in rat brain cytozol [83].
RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release.
Inositol 1,4,5-trisphosphate (IP3) and 1,2-diacylglycerol (DAG) are produced during the activation of phospholipidase C (PLC), which activates PKC, and subsequently induce the phosphorylation of p47 [17].