inositol

(redirected from Inositol 1,4,5-trisphosphate)
Also found in: Thesaurus, Medical, Encyclopedia.

in·o·si·tol

 (ĭ-nō′sĭ-tôl′, -tōl′, ī-nō′-)
n.
Any of nine isomeric alcohols, C6H12O6·2H2O, that are precursors to various signaling molecules.

[Greek īs, īn-, sinew; see wei- in Indo-European roots + -os(e) + -it(e) + -ol.]

inositol

(ɪˈnəʊsɪˌtɒl)
n
(Chemistry) a cyclic alcohol, one isomer of which (i-inositol) is present in yeast and is a growth factor for some organisms; cyclohexanehexol. Formula: C6H12O6
[C19: from Greek in-, is sinew + -ose2 + -ite1 + -ol1]

in•o•si•tol

(ɪˈnoʊ sɪˌtɔl, -ˌtoʊl, aɪˈnoʊ-)

n.
a compound, C6H12O6, occurring in animal tissue, plants, and many seeds, that functions as a growth factor.
[1890–95; inosite an earlier name (< Greek īn-, s. of is fiber, sinew + -ose2 + -ite1) + -ol1]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.inositol - an optically inactive alcohol that is a component of the vitamin B complex
B complex, B vitamin, B-complex vitamin, vitamin B, vitamin B complex, B - originally thought to be a single vitamin but now separated into several B vitamins
Translations
inositol
References in periodicals archive ?
They mediate the ER-associated degradation (ERAD) pathway which is responsible for the degradation of misfolded proteins in the ER such as activated inositol 1,4,5-trisphosphate (IP[sub]3) receptors and other substrates in mammalian cells.
2+] into the cytoplasm refer to the inositol 1,4,5-trisphosphate receptor ([IP.
Putative inositol 1,4,5-trisphosphate binding protein in rat brain cytozol [83].
RACK1 binds to inositol 1,4,5-trisphosphate receptors and mediates Ca2+ release.
19),(35) mGluR1 is coupled to Gq protein and activates phospholipase C, which produces inositol 1,4,5-trisphosphate (IP3) and diacylglycerol.
Assessment of the role of the inositol 1,4,5-trisphosphate receptor in the activation of transient receptor potential channels and store-operated [Ca.
Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor.
PLC-r2 catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate, generating inositol 1,4,5-trisphosphate and diacylglycerol.
Mikoshiba and colleagues demonstrated that a neuronal protein called inositol 1,4,5-trisphosphate receptor 1 (IP3R1) which regulates cellular calcium signaling was destroyed by ER stress and subsequently induced neuronal cell death and brain damage.