integrin


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in·te·grin

 (ĭn′tə-grĭn)
n.
Any of a group of transmembrane proteins that bind to certain molecules in the extracellular matrix or on the surface of other cells. They are involved in cell adhesion and motility and in the transmission of signals across the plasma membrane.

integrin

(ɪnˈtɛɡrɪn)
n
a protein that acts as a signal receptor between cells
References in periodicals archive ?
Vedolizumab, a gut-selective immunosuppressive biologic, is a humanized monoclonal antibody that is designed to specifically antagonize the alpha4beta7 integrin, inhibiting binding to intestinal mucosal addressin cell adhesion molecule 1 (MAdCAM-1) and fibronectin, but not vascular cell adhesion molecule 1 (VCAM-1).
Leukocyte adhesion deficiency (LAD) is a rare primary immunodeficiency disorder with autosomal recessive inheritance which is characterized by presence of a defect of phagocytic function resulting from a lack of leukocyte cell surface expression of b2 integrin molecules (CD11 and CD18) that are essential for chemotaxis.
Methods: Metastasis-associated MR molecular imaging probe, integrin a[sub]v[sz][sub]3ligand cRGD-PEG-DGL-DTPA-Gd (Gd-RGD), were constructed.
It has been found that CIB1 acts as a specific binding adjunct for the cytoplasmic domain of the platelet integrin [alpha]IIb subunit (5).
A glue-like protein, called an integrin, that helps cells stick together and assemble into tissue and organs, was used in the experiment.
M2 EQUITYBITES-August 11, 2017-Allegro Ophthalmics' Luminate integrin peptide therapy passes phase two trial
1 integrin, in affected muscle cells could alleviate DMD symptoms in a mouse model.
Most of these receptors belong to integrin receptor family.
The new organisation unites Antegrin's portfolio of small-molecule integrin antagonists with the drug-development expertise, seasoned executive experience, and track record of Cascadia.
At the molecular level, thyroid hormone has cell surface receptors for integrin [alpha]v[beta]3 that mediates the angiogenic activity of thyroid hormones and integrin [alpha]v[beta]3 has proangiogenic effects on growth factors implicated in the pathogenesis of retinal new vessels, (3) including erythropoietin, growth hormone, Basic Fibroblast Growth Factor (bFGF), insulin-like growth factor-1 (IGF-1) and Vascular Endothelial Growth Factor (VEGF).
The researchers determined that the function of integrins (specifically, the protein [beta]1-integrin) is absolutely crucial for maintaining the cycle of hibernation, activation, proliferation, and then return to hibernation, in muscle stem cells.
Extra doses of a protein called alpha5beta1 integrin may also give the cancer-associated fibroblasts extra handholds on fibers.