Development of interglobular
dentine in rat molars and its relation to maturation of enamel.
Blocking aggrecanase cleavage in the aggrecan interglobular
domain abrogates cartilage erosion and promotes cartilage repair.
Hughes et al., "Aggrecanase versus matrix metalloproteinases in the catabolism of the interglobular
domain of aggrecan in vitro," Biochemical Journal, vol.
He described that these "interglobular
spaces" are always present but variable in their amount.
After the cessation of enamel secretion, a substantial variation of mineral content in dentin can be seen with occasional bands of interglobular
dentin [7, 8].
Evidence for the involvement in osteoarthritis of a novel proteinase which cleaves the Glu 373-ala 374 bond of the interglobular
domain," The Journal of Clinical Investigation, vol.
spaces and cellular and amorphous areas are prominent.