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Any of various small proteins that are produced by a variety of cell types, especially T cells and other white blood cells, and that regulate many aspects of inflammation and the immune response, including stimulating the production of white blood cells and platelets.


(Biochemistry) a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer


(ˈɪn tərˌlu kɪn)
any of a family of small proteins that participate in the body's defense system, esp. by promoting the growth and activation of white blood cells.
[1979; inter- + leuk (ocyte) + -in1; so called because such proteins act as agents of communication between different populations of leukocytes]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.interleukin - any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
lymphokine - a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages)
References in periodicals archive ?
In the gene study, Chiocca and his colleagues injected brain tumors with viruses carrying a gene that promotes the production of interleukin-12, a biochemical that prompts the immune system to find and fight cancer.
Expression of Toll-like receptors 2 and 4 in rheumatoid synovial tissue and regulation by proinflammatory cytokines interleukin-12 and interleukin-18 via interferon-I3.
The late-stage cancer biotechnology company develops intratumoral gene-delivery immunotherapies, including its lead immunotherapy platform TAVO (tavokinogene telseplasmid), which enables the intratumoral delivery of DNA-based interleukin-12 (IL-12), a naturally occurring protein with immune-stimulating functions.
"We are pleased the FDA has granted Fast Track designation and continue to believe this investigational drug has the potential to safely harness the power of interleukin-12, which in turn activates the patient's own immune system to attack this cancer and extend overall survival."
The structure of interleukin-23 reveals the molecular basis of p40 subunit sharing with interleukin-12. J Mol Biol.
lipid antigen) in association with interleukin-12 (IL-12).
Function and clinical use of interleukin-12. Curr Opin Hematol 1997;4:59-66.
TAVO enables the intratumoral delivery of DNA-based interleukin-12, a naturally occurring protein with powerful immune-stimulating functions.
The results from this assay suggested that LPS injection significantly increased the concentration of tumor necrosis factor-[alpha] (TNF-[alpha]) in bursa of Fabricius (P<0.05), along with an increase in the concentrations of immunoglobulin-G (IgG) and interleukin-12 (IL-12) in the serum of ducks at 1 day and 7 days after LPS injection (P0.05).
In another study it was found out that lisinopril supresses production of interleukin-12 and interferon [gamma] by human peripheral blood mononuclear cells thus contributing to immunomodulatory effect of lisinopril and which has beneficial effect in inflammatory or autoimmune conditions involving interleukin 12.
Recent studies have suggested a genetic defect in the interleukin-12 (IL-12) and interferon-gamma pathways as predisposing factors for this disease form.