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Any of various small proteins that are produced by a variety of cell types, especially T cells and other white blood cells, and that regulate many aspects of inflammation and the immune response, including stimulating the production of white blood cells and platelets.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biochemistry) a substance extracted from white blood cells that stimulates their activity against infection and may be used to combat some forms of cancer
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈɪn tərˌlu kɪn)
any of a family of small proteins that participate in the body's defense system, esp. by promoting the growth and activation of white blood cells.
[1979; inter- + leuk (ocyte) + -in1; so called because such proteins act as agents of communication between different populations of leukocytes]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.interleukin - any of several lymphokines that promote macrophages and killer T cells and B cells and other components of the immune system
lymphokine - a cytokine secreted by helper T cells in response to stimulation by antigens and that acts on other cells of the immune system (as by activating macrophages)
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
KEYWORDS: Rheumatoid arthritis, Interleukin-18, Disease modifying anti-rheumatic drugs, Gene expression.
Plasma interleukin-18 is associated with viral load and disease progression in Hiv-1-infected patients.
Elevated plasma interleukin-18 is a marker of insulin-resistance in type 2 diabetic and non-diabetic humans.
Greater decreases in albumin-creatinine ratio (ACR), interleukin-18, anti-chitinase-3-like protein 1 (YKL-40), and uromodulin were seen in incident CKD participants in the intensive group versus matched control participants after one year of blood pressure intervention.
Increased expression of interleukin-18 in the trigeminal spinal subnucleus caudalis after inferior alveolar nerve injury in the rat.
The role of interleukin-1 and interleukin-18 in pro-inflammatory and anti-viral responses to rhinovirus in primary bronchial epithelial cells.
Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability.
Interleukin-18 (IL-18), a member of the IL-1 family of cytokines, is synthesised as an inactive 23 kDa precursor by several tissues including proximal tubular epithelial cells, macrophages and monocytes.
Interleukin-18 (IL-18) is an important Th1 cytokine and plays an important role in pregnancy.
Several novel biomarkers have shown promising results in predicting AKI after cardiac procedures: neutrophil gelatinase-associated lipocalin (NGAL), which is involved in the innate immune system and allows earlier detection of AKI than SCr; kidney injury molecule-1 (KIM-1), a type-1 transmembrane protein; and interleukin-18 (IL-18), a proinflammatory cytokine that plays a role in both the innate and acquired immune response.
(7) Interleukin-18 (IL-18) is a pleiotropic proinflammatory cytokine, which is mainly produced by macrophages and plays a central role in the inflammatory cascade.
angulata whole fruit (WF) juice administered at 0.5, 1.0, and 1.5 ml/kg/day on 11 serum inflammatory biomarkers (cytokines) of atherosclerosis such as interleukin-1 (IL-1), interleukin-2 (IL-2), interleukin-6 (IL-6), interleukin-7 (IL-7), interleukin-8 (IL-8), interleukin-18 (IL-18), intercellular cell adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), C-reactive protein (CRP), tumor necrosis factor-[alpha] (TNF-[alpha]), and P-selectin in rabbits fed high-cholesterol diet.