Using mice deficient in nestin, a protein that is a component of the part of the cytoskeleton known as intermediate filaments
or nanofilaments, the research team showed that nestin produced in astrocytes has an important role in inhibiting neuronal differentiation.
Nerve pathology of GAN shows typical giant axon with accumulating intermediate filaments
. The disease is progressive with impairments in both peripheral and central nervous system.
'Hard' and 'soft' principles defining the Structure, function and regulation of keratin intermediate filaments
. Curr Opin Cell Biol 2002;14:110-22.
The contractile proteins actin and myosin, together with the structural proteins (e.g., titin and nebulin) and intermediate filaments
, create a solid and efficient muscular architecture.
(1,2) The disease stems from gigaxonin gene mutations resulting in disorganization of axonal intermediate filaments
. (2) Pronounced peripheral motor and sensory neuropathy begins in infancy, and the disease progresses centrally with cognitive impairment, seizures and pyramidal tract signs.
According to Wayne Vogl et al, unlike most other epithelia where the intermediate filaments
are of keratin type, intermediate filaments
in mature Sertoli cells are of the vimentin type (32).
In mitotically active cells, nestin plays an important role, regulated by phosphorylation, in the assembly and disassembly of intermediate filaments
, which contributes to remodeling the cytoskeleton of the cells.
The desmosomes mediate direct cell-to-cell contact by providing anchoring sites for intermediate filaments
, being necessary for electrical conduction, mechanical contraction , participating also in tissue morphogenesis and differentiation .
Recognizing that a single volume could never cover the breadth of recent research into the cytoskeleton, medical and biological researchers provide snapshots that capture the basic properties of each of the three major cytoskeletal systems: actins, intermediate filaments
, and microtubules.
 have also shown that a significant number of MM cases may demonstrate aberrant expression of intermediate filaments
are dynamic and motile elements of cellular architecture.