Scientists are now developing other agents that are specifically designed to act selectively on a particular target within a particular intracellular signaling pathway
within a particular set of cells.
Background: Resistance to endocrine therapy in breast cancer is associated with activation of the mammalian target of rapamycin (mTOR) intracellular signaling pathway
Streamlined for highly selective assays, Tag-lite offers a comprehensive reagent and method selection for the investigation of G-protein coupled receptor (GPCR) binding and mechanistics, and preserves the functionality of the receptor and the intracellular signaling pathway
Researchers at the University of California, San Diego, found that sweet, bitter and umami tastes are transmitted from the various taste receptors via a common intracellular signaling pathway
-- at least in mice.
In our study, we used mouse and zebrafish model systems to identify a novel intracellular signaling pathway
that controls stress-induced CRH gene expression," he said.
Intracellular signaling pathways
involved in Gas6-Axl-mediated survival of endothelial cells.
Experiments in isolated human T cells demonstrated that these GLUT inhibitors blocked the secretion of pro-inflammatory cytokines, such as IL-17 and TNF-alpha, and modulated key intracellular signaling pathways
in pathogenic T cells, including STAT1, STAT3 and S6K.
Antioxidants can have remarkable effects on the intracellular signaling pathways
involved in preventing skin damage.
5) Copper is toxic in its unbound form, causes redox imbalance due to its highly redox active nature, which leads to activation of stress sensitive intracellular signaling pathways
through Haber-Weiss reaction (6,7) The present study was undertaken to study the relationship between fasting plasma glucose (FPG) and copper with ceruloplasmin in type 2 DM patients