Homologous rearrangements of acrocentric chromosomes can result in either isochromosomes
or ROBs (24).
It is likely that a complete genomic characterization of CLL requires a combination of fluorescence in situ hybridization (FISH), single nucleotide polymorphism (SNP) array profiling for comprehensive genome-wide analysis of acquired genomic copy number aberrations (aCNAs) and loss-of-heterozygosity (LOH) in dominant clones, and karyotyping for detection of balanced translocations, isochromosomes
, and marker chromosomes.
Stahlschmidt and colleagues reported several numerical and structural chromosome changes, including isochromosomes
for 1q, 8q and 17q, translocation between chromosomes 10 and 16, and between chromosomes 9 and 22, and rearrangement of the chromosomes 22 at q11.
Among the structural aberrations in adult ALL, deletions and isochromosomes
were the second most frequent changes after translocations (7), (11), (33).
Polysomy and supernumerary isochromosomes
in the grasshopper Omocestus bolivari (Chopard).
In addition to the reconstructed chromosomes 2B and 2R, among the progeny screened there were several plants with telocentric chromosomes 2RS, 2RL, 2BS, or 2BL, with isochromosomes
2RS, 2BS, and 2BL, and centric translocations 2BS.2RS and 2BL.2RL (Fig.