Phytochemical analysis of the NHE and structural elucidation of compound 1: The NHE was found to contain isoprenoids
(triterpenoid/steroids, cardenolides) and fatty acids as metabolites from phytochemical screening using appropriate standard reagents.
The biomarkers data were obtained from gas chromatography (GC) and gas chromatography-mass spectrometry (GC-MS) analysis of normal alkanes, isoprenoids
, triterpene, and steranes.
The cholesterol de novo synthesis is also responsible for provision of isoprenoids
which provide lipid anchorage for many proteins making them able to take part in transduction of signals and metabolism.
pristane (Pr) and phytane (Ph) are abundant in all oil shale samples (Fig.
15 phytochemicals including 5 fatty acids, methyl iso-pentadecanoate (37), methyl pentadecylate (40), isopropyl myristate (41), methyl elaidate (56), and 9Z,12E-Octadecadienoic acid ME (60); 2 fatty aldehydes, nonanal (16) and 2E-decenal (20); 2 fatty alcohols, lignocerol (68) and pentacosyl alcohol (73); 4 isoprenoids
, phytane (36), iso-phytol (42), hexahydrofarnesyl acetone (43), and E-phytol (57), and 2 phytosteroids, O-Sitosterol (79) and fucosterol (81) were identified for the first time from S.
The function of plastid (apicoplast) in Apicomplexa is unclear, but many studies suggested its roles in the biosynthesis of fatty acids, haem, isoprenoids
, and Fe-S cluster, based on the analysis of genome sequence.
Predatory bacteria are different from the nonpredators based on the pathway utilized for the biosynthesis of isoprenoids
. While the nonpredators use the deoxy-d-xylulose 5-phosphate (DOXP) or nonmevalonate pathway, the predators use the mevalonate pathway for the biosynthesis of isoprenoids
The mechanisms underlying the effects of statins on renal structural protection are still speculative, but may be related to their ability to prevent synthesis of certain isoprenoids
that prevent post-translational modification of proteins such as Ras and Rho.
Biosynthesis of the Irregular Monoterpene Artemisia Ketone, the Sesquiterpene Germacrene D and Other Isoprenoids
in Tanacetum vulgare L.
Identification of aryl isoprenoids
was achieved through analysis of mass spectra, retention time, and comparison with literature data [33-36].
DEINOVE has validated the 2nd key milestone of the DEINOCHEM program, dedicated to the production of biosourced isoprenoids
, funded by ADEME (French Environment and Energy Management Agency) in the framework of the Investments for the Future program launched by the French government.