There is an association between single nucleotide polymorphism variants of KITLG
and risk of testicular GCTs, and thus it is plausible that interference with KIT signaling between Sertoli cells and gonocytes plays a mechanistic role.
Conclusion: In conclusion, the results revealed that niche cells respond to SSCs removal by upregulation of GDNF and FGF2, and downregulation of KITLG in order to stimulate self-renewal and arrest differentiation.
Conversely, KITLG has been found to play a pivotal role in SSCs differentiation (4,10).
The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG
, also known as stem cell factor.
During their study, they found one of the variants affecting a p53 binding site was located in the KITLG
gene, which is linked to testicular cancer.
Common genes regulated by WB, FR-D and imipramine were GRIA 2 [down arrow], SRP54 [down arrow], CYP26B [down arrow], DNM1L [up arrow] and KITLG
But in an unusual twist, it is a common version of the gene, called KITLG
, that is harmful.
Genes for kinases and kinase inhibitors, such as the CDKN2B, DOK1, KITLG
, MAP4K4, NPM1, and PTK2B genes are also included in the panel.
Our observed strong association is intriguing and may reflect the impact of the genetic effect of KITLG
," said co-researcher Dr.