The researchers found that the blond hair commonly seen in Northern Europeans is caused by a single change in the DNA that regulates the expression of a gene that encodes a protein called KITLG
, also known as stem cell factor.
During their study, they found one of the variants affecting a p53 binding site was located in the KITLG
gene, which is linked to testicular cancer.
Common genes regulated by WB, FR-D and imipramine were GRIA 2 [down arrow], SRP54 [down arrow], CYP26B [down arrow], DNM1L [up arrow] and KITLG
But in an unusual twist, it is a common version of the gene, called KITLG
, that is harmful.
Genes for kinases and kinase inhibitors, such as the CDKN2B, DOK1, KITLG
, MAP4K4, NPM1, and PTK2B genes are also included in the panel.
Our observed strong association is intriguing and may reflect the impact of the genetic effect of KITLG
," said co-researcher Dr.