PSA

(redirected from KLK3)
Also found in: Thesaurus, Medical, Financial, Encyclopedia.

PSA

abbr.
1. prostate-specific antigen
2. public service announcement
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

PSA

abbreviation for
1. (Biochemistry) prostatic specific antigen: an enzyme secreted by the prostate gland, increased levels of which are found in the blood of patients with cancer of the prostate
2. (Social Welfare) (in New Zealand) Public Service Association
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

PSA

prostate specific antigen: a protein, produced by the prostate, elevated levels of which may indicate the presence of cancer.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.PSA - a protein manufactured exclusively by the prostate gland; PSA is produced for the ejaculate where it liquifies the semen and allows sperm cells to swim freely; elevated levels of PSA in blood serum are associated with benign prostatic hyperplasia and prostate cancer
protein - any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
Translations

PSA

abbr prostate-specific antigen. V. antigen.
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
KLK2, KLK3 (kallikreins), and IGF1R were downregulated, whereas IGFBP3 was upregulated by melatonin (pharmacological doses: 10-20 mg/l in drinking water, for 18 weeks), demonstrating the role of the IGF signaling pathways in the oncostatic effect of the pineal hormone [88].
Analyzing DLX1 and HOXC6 biomarkers, using KLK3 expression as internal reference combined with age, DRE results, and PSA level, this test provides percent likelihood of having any prostate cancer and percent likelihood of having high-grade prostate cancer (Leyten et al., 2015; Van Neste, Hendriks et al., 2016).
A large-scale analysis of genetic variants in miRNA binding sites identified 22 prostate cancer risk associated miRSNPs, the 2 most significant miRSNPs being KLK3 (kallikrein related peptidase 3) rs1058205 (T>C) and VAMP8 (vesicle associated membrane protein 8) rs1010 (A>G), which were targeted by miR-3162-5p and miR-370-5p respectively in an allele specific manner (77).
Of note, the prostate-specific antigen (PSA [kallikrein3 protein; KLK3, gene]) is expressed and secreted by human but not mouse luminal prostate cells, which secrete other proteins that seem to be lobe-specific [39, 40].
They analysed associations of the SNPs with disease aggression and found that the KLK3 gene can predict an aggressive form of GS7 disease.
In the study by Gudmundsson et al., KLK3 encodes PSA was one of the six loci identified by GWAS that were associated with higher PSA levels in patients without prostate cancer [151].
A list of candidate biomarkers was chosen according to a set of criteria, highlighting KLK6, a protein that belongs to the 15-member KLK family in which KLK3 (also known as prostate-specific antigen) is the most useful marker for the early detection of prostate cancer.
A list of environmental indicators Environmental indicators Category Name Notation Natural Fossil energy use during transportation KEF1 resource use Fossil energy use during loading-unloading KEF2 Rate of using renewable resources KEF3 Energy Energy efficiency of transportation KE1 efficiency Technology Level of technology involved during vehicle KT1 construction Emissions Total C[O.sub.2] emissions KLK1 to air Total N[O.sub.x] emissions KLK2 Total PM emissions KLK3 Total S[O.sub.2] emissions KLK4 Emissions to Emissions to soil and water KFV1 soil and water Waste generation KFV2 Table 3.
PSA and human kallikrein 2 are closely related products of human kallikrein genes KLK3 and KLK2, respectively.
The image represents an imaginary structure of PSA (also known as KLK3) looking at one of its substrates (upper right).
The genes that were more highly expressed in carcinomas treated with androgen ablation agents included those encoding AR and steroid biosynthetic enzymes, as well as a suite of genes that have been previously shown to be targets of AR or have been implicated as being regulated by it, including the gene encoding PSA (kallikrein-related peptidase 3), KLK3, and KLK2, as well as DBI, FASN, IL6, SERPINB5, TGFBR3, TMPRSS2, TUBA1, HOXC6, TRG ,and FOLH1.