kinase

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ki·nase

 (kī′nās′, -nāz′, kĭn′ās′, -āz′)
n.
Any of various enzymes that catalyze the transfer of a phosphate group from a donor, such as ADP or ATP, to an acceptor protein. Kinases regulate many essential cellular processes.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

kinase

(ˈkaɪneɪz; ˈkɪn-)
n
1. (Biochemistry) any enzyme that can convert an inactive zymogen to the corresponding enzyme
2. (Biochemistry) any enzyme that brings about the phosphorylation of a molecule
[C20: from kin(etic) + -ase]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ki•nase

(ˈkaɪ neɪs, -neɪz, ˈkɪn eɪs, -eɪz)

n.
an enzyme that effects the transfer of a phosphate group from ATP to another molecule.
[1900–05; kin (etic) + -ase]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.kinase - an enzyme that catalyzes the conversion of a proenzyme to an active enzyme
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
In this review, we focus on the pattern of the generation and homeostasis of intracellular ROS, the mechanisms and targets of ROS impacting on cell-signaling proteins, ion channels and transporters, and modifying kinases and Ubiquitination/Proteasome System.
The traditional cytoplasmic EGFR-initiated route involves transduction of mitogenic signals through activation of several signaling cascades, such as phospholipase C[gamma], protein kinase C, mitogen-activated protein kinases, phosphatidyl i nositol-3-kinase, and signal transducer and activator of transcription (STATs) (Bae et al.
The Aurora kinases belong to a family of serine/threonine kinases having in the Ipl1p (increase in ploidy 1) gene, subsequently named Aurora gene, the founding member discovered in the budding yeast Saccharomyces cerevisiae during a genetic screening for mutations causing defective chromosomal segregation [1].
Additionally the membrane associated growth factor receptor (GFR) induced survival signaling pathway, and recruitment of oncogenic signals for nuclear transcriptional regulation could be aberrant due to aberrant activity of GSK3beta as demonstrated earlier [20], while involvement of intermediary survival kinases with apparent deregulation of splicing factors is sparsely understood.
The company is the provider of kinase-based discovery services, with 650 kinases covered in the industry's largest offering of its kind.
Fundamentally, R-genes are classified into 8 major classes based on the arrangement of domains mainly consisting NBS, LRR and kinases (28).
Avapritinib is a potent and selective inhibitor of activated KIT and PDGFRA mutant kinases. Currently approved TKIs only bind to the inactive conformations of KIT and PDGFRA, whereas avapritinib is designed to bind and inhibit the active conformation of these protein kinases.
Summary: The PIM kinases are a family of serine/threonine kinases that catalyze the ATP dependent phosphorylation.
PTP-1B is ubiquitous in tissues and regulates several metabolic processes, including the function of receptor tyrosine kinases (RTKs) such as the platelet-derived growth factor (PDGF) and epidermal growth factor receptor (EGFR).
Phosphorylation is catalyzed by protein kinases and usually leads to a functional change, by changing cellular location, enzyme activity, or related to other proteins, of the target protein (substrate) [4, 5].