kinetochore

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ki·net·o·chore

 (kə-nĕt′ə-kôr′, -nē′tə-, kī-)
n.
Either of two submicroscopic attachment points for chromosomal microtubules, present on each centromere during the process of cell division.

[kineto- + Greek khōros, place; see -chore.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

kinetochore

(kɪˈnɛtəˌkɔː; kɪˈniːtəˌkɔː; kaɪˈnɛtəˌkɔː; kaɪˈniːtəˌkɔː)
n
(Genetics) a centromere, a protein structure found in chromosomes
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

ki•ne•to•chore

(kɪˈni təˌkɔr, -ˌkoʊr, -ˈnɛt ə-, kaɪ-)

n.
a structure on the chromosome, at or near the centromere, to which spindle fibers attach during cell division.
[1930–35; < Greek kīnetó(s)]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.kinetochore - a specialized condensed region of each chromosome that appears during mitosis where the chromatids are held together to form an X shape; "the centromere is difficult to sequence"
anatomical structure, bodily structure, body structure, complex body part, structure - a particular complex anatomical part of a living thing; "he has good bone structure"
chromosome - a threadlike strand of DNA in the cell nucleus that carries the genes in a linear order; "humans have 22 chromosome pairs plus two sex chromosomes"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Motile kinetochores and polar ejection forces dictate chromosome position on the vertebrate mitotic spindle.
Interestingly, CENP-E is involved in the initial alignment of chromosomes at the spindle equator on the metaphase plate, and therefore, it is required for steady spindle microtubule capture at the kinetochores, which is a critical step in proper chromosome congression during prometaphase.
Chromosome segregation is controlled by kinetochores, which guarantee the fidelity of segregation (36).
Normally, the process is regulated by a spindle assembly checkpoint that monitors attachment of the spindle microtubules to kinetochores of chromosomes (Doxsey et al.
Nicklas, "Chromosomes and kinetochores do more in mitosis than previously thought," in Chromosome Structure and Function, Stadler Genetics Symposia Series, J.
The SAC can prevent aneuploidy by delaying chromosome segregation at prometaphase or metaphase in response to unattached kinetochores and DNA damage during preimplantation development [9, 14-16].
Additionally, it dislocates the centromere protein-F (CENP-F) from kinetochores [16].
In Drosophila, both midzone-derived and astral stimulation signals likely contribute to equatorial stimulation, while recent work (Rodrigues et al., 2015) suggests that polar relaxation is mediated by a phosphatase gradient emanating from kinetochores. We have shown that a midzone-based aurora kinase activity gradient that requires both mABK and a predominantly soluble pool of AAK contributes to the fidelity of cytokinesis.
Scientists from Japan, Europe, and the US discuss the history of mitosis research and the model systems that have played a key role; how threads are produced through chromosome condensation; how sister chromatids attach to each other and to the spindle apparatus; how the spindle microtubules nucleate, elongate, pause, and shrink; how kinetochores and centrosomes serve as anchor and control points; the biochemical elements that coordinate the main regulatory stages of entry into mitosis, sister chromatid separation, and mitotic exit; how cells can mis-segregate and unbalance the genome; the cellular changes that occur during cytokinesis; and the differences between mitosis and meiosis.
Not surprisingly, APC/[C.sup.Cdc20] is a target of the spindle checkpoint, not allowing the degradation of securin until proper attachment and alignment of all kinetochores to the spindle are completed [23].
de Mey, "Taxol induces the assembly of free microtubules in living cells and blocks the organizing capcity of the centrosomes and kinetochores," Proceedings of the National Academy of Sciences of the United States of America, vol.