Kupffer's cell

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Related to Kupffer's cell: stellate cell, Ito cell
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Noun1.Kupffer's cell - specialized cells in the liver that destroy bacteria, foreign proteins, and worn-out blood cells
cell - (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
liver - large and complicated reddish-brown glandular organ located in the upper right portion of the abdominal cavity; secretes bile and functions in metabolism of protein and carbohydrate and fat; synthesizes substances involved in the clotting of the blood; synthesizes vitamin A; detoxifies poisonous substances and breaks down worn-out erythrocytes
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In addition, ethanol increases endotoxin bypass from leaky gut which triggers Kupffer's cell activation and inflammatory processes.
As part of the lobular activity, enlargement and hyperplasia of Kupffer's cells in sinusoids were studied (0--no change, 1--light hyperplasia of Kc, 2--moderate hyperplasia of Kc, and 3--severe hyperplasia of Kc).
rohita, Control, indicating normal hepatocytes histology, brown arrow indicates Kupffer's cells, while yellow arrow indicates the polygonal hepatocytes with centrally placed nucleus.