Kynurenic


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Ky`nu`ren´ic


a.1.(Physiol. Chem.) Pertaining to, or designating, an acid obtained from the urine of dogs. By decomposition the acid yields a nitrogenous base (called kynurin) and carbonic acid.
References in periodicals archive ?
It is concluded that DS inhibits hepatic TDO enzyme activity following chronic treatment, while augments brain IDO activity following both acute and chronic DS treatment, this may result in rise in cerebral kynurenic acid and/or quinolinic acid concentrations.
6]/well) plates, grown for 16 h, treated with herbal extracts (lO [micro]g/ml) or kynurenic acid (KYNA) (10 [micro]M) for 8h, followed by treatment with or without [MPP.
The immune response to influenza and other viruses involves cell-mediated immunity and cytokine activity, which tend to turn tryptophan into kynurenic instead of serotonin.
Because this chemical, kynurenic acid, has also been implicated in many human diseases, including neurodegenerative conditions such as Alzheimer s disease and Huntington s disease, the finding may provide useful clues for understanding and treating these disorders.
Regulation of GABAergic inputs to CA1 pyramidal neurons by nicotinic receptors and kynurenic acid.
A synthetic analogue of kynurenic acid, a naturally occurring neural regulatory compound, 7-C1KYNA is one of the most potent and selective blockers of the regulatory GlyB-site of the NMDA receptor.
Folate (5-methyltetrahydrofolate), riboflavin, flavin mononucleotide (FMN), [7] FAD, pyridoxal 5'-phosphate (PLP), pyridoxal (PL), pyridoxic acid, free choline, betaine, dimethylglycine, creatinine, methionine sulfoxide, arginine, asymmetric dimethylarginine (ADMA), symmetric dimethylarginine (SDMA), tryptophan, kynurenine, kynurenic acid, anthranilic acid, 3-hydroxykynurenine, xanthurenic acid, 3-hydroxyanthranilic acid, and formiminoglutamic acid, were determined by liquid chromatography--tandem mass spectrometry (14-17), and methylmalonic acid, total homocysteine, total cysteine, methionine, serine, glycine, cystathionine, and sarcosine by gas chromatography-tandem mass spectrometry (15, 18).
For the first time, scientists at the University of Maryland School of Medicine have linked a brain compound called kynurenic acid to cognition, possibly open doors for new ways to enhance memory function and treat catastrophic brain diseases.
Using the PIT model, we next used kynurenic acid treatment to counteract key molecules identified by the Gene Chip and observed differential rates of behavioral recovery after infarction (10).
Age-related increase of kynurenic acid in human cerebrospinal fluid - IgG and beta2microglobulin changes.