asparaginase

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Related to L-asparaginase: methotrexate, cyclophosphamide, etoposide, vincristine

as·par·a·gin·ase

 (ə-spăr′ə-jə-nās′, -nāz′)
n.
An enzyme isolated from bacteria that catalyzes the hydrolysis of asparagine and is used in the chemotherapeutic treatment of leukemia.

asparaginase

(əˈspærədʒɪˌneɪz; əˈspærədʒɪˌneɪs)
n
(Pharmacology) an enzyme used in treating leukaemia
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.asparaginase - antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemiaasparaginase - antineoplastic drug (trade name Elspar) sometimes used to treat lymphoblastic leukemia
antineoplastic, antineoplastic drug, cancer drug - any of several drugs that control or kill neoplastic cells; used in chemotherapy to kill cancer cells; all have unpleasant side effects that may include nausea and vomiting and hair loss and suppression of bone marrow function
References in periodicals archive ?
A Prospective, Open-Label Study Evaluating Treatment of Canine B-cell Lymphoma with L-Asparaginase, Doxorubicin and a Canine Anti-CD20 Monoclonal Antibody
Invitation to tender: drugs of the l-compositions to treat malignancies (lapatinib, l-asparaginase, topotecan, irinotecan, megestrol acetate)
Erwinaze is contraindicated in patients with a history of serious hypersensitivity reactions to Erwinaze, including anaphylaxis; or where serious pancreatitis, serious thrombosis or serious hemorrhagic events occurred with prior L-asparaginase therapy.
Urease, L-glutaminase, L-asparaginase, alkaline phosphomonoesterase, and arylsulfatase activities were determined in the rhizospheric soil according to the protocols described by Tabatabai [16, 17].
L-asparaginase has been a mainstay in the treatment of children suffering from ALL, but its use is limited in older and fragile patients due to its toxicity profile.
Up to 20% of patients receiving L-asparaginase exhibit marked dyslipidemia [triglycerides >1000 mg/dL (> 11.
L-asparaginase, which is used in the treatment of leukaemia, can cause coagulopathy due to a decrease in antithrombin III and fibrinogen.
Guinea pigs have in their blood an enzyme called L-asparaginase, which destroys the amino acid L-asparagine.
1,2) AP in association with ALL has been reported previously, but the connection was mainly related to chemotherapeutic agents, namely L-asparaginase.