BARCELONA -- The maxim that lower is better for
LDL cholesterol continues to hold true, even at jaw-droppingly low levels of less than 10 mg/dL, in a new analysis of data from the FOURIER trial.
Inclisiran lowers low-density lipoprotein (LDL; bad) cholesterol for up to one year in patients with high cardiovascular risk and elevated
LDL cholesterol, according to late-breaking results from the ORION 1 trial presented today in a Hot Line LBCT Session at ESC Congress.
Now, a meta-analysis suggests that oats can also reduce two other markers of cardiovascular disease: non-HDL cholesterol (total cholesterol minus the "good" HDL cholesterol), and apolipo-protein B (apoB), a substance that carries
LDL cholesterol through the blood.
Sabatine, of Brigham and Women's Hospital at Harvard Medical School in Boston, MA, and colleagues note that the clinical benefits of using statins to lower
LDL cholesterol are widely accepted, largely due to the high-quality evidence of their safety and efficacy in clinical trials.
It's called "The Rule of Six," because every increase in statin dosage equates to a six percent improvement in
LDL cholesterol.
We recently found genetically increased concentrations of nonfasting remnant cholesterol, like increased
LDL cholesterol concentrations, to be causally associated with increased ischemic heart disease (IHD) (5) risk (4, 5), independent of low concentrations of HDL cholesterol (4).
The researchers found that both male and female study participants who took a statin reduced their risk of a major cardiovascular event (heart attack, stroke, bypass surgery, cardiac death) by 21 percent and the overall risk of death by nine percent for every 1 millimole per liter (mmol/L) reduction in
LDL cholesterol.
1) But much lower percentages of these people reached blood pressure or
LDL cholesterol targets with treatment.
LDL cholesterol is considered "bad," in contrast to high-density lipoprotein (HDL) cholesterol, which is considered "good.
WASHINGTON -- High-risk patients managed to a target LDL particle number rather than to an
LDL cholesterol goal had 25% fewer cardiovascular events over 3 years of follow-up.
30,2013 in JAMA Neurology suggests that having high levels of "bad"
LDL cholesterol and low levels of "good" HDL cholesterol increases your risk of developing the toxic beta-amyloid plaques that are a hallmark of Alzheimer's disease (AD).
Diets emphasizing dietary pulse intake at a median dose of 130 g/d (about 1 serving daily) significantly lowered
LDL cholesterol levels compared with the control diets (mean difference -0.
