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Any of a class of filamentous proteins that form a meshlike layer inside the nuclear membrane of animal cells and have a variety of functions, including providing mechanical support for the nucleus, organizing chromatin, and regulating DNA replication and transcription.

[lam(ina) (in reference to the nuclear lamina, where lamins are found ) + -in.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
References in periodicals archive ?
Nuclear titin interacts with A- and B-type lamins in vitro and in vivo.
The function of lamins in the context of tissue building and maintenance.
Lamins are intermediate filament proteins in the nuclear lamina and the cellular matrix and are critical determinants of nuclear architecture.
The first genetic model for the study of laminopathy was the Lmna knockout mouse, which has become one of the most frequently used models to determine relationships between physiological functions of nuclear lamins and their contribution to the molecular pathophysiology of laminopathies.
Lamins are proteins that the major structural component of the material that lines the inside of a cell's nucleus.
A group of human diseases called laminopathies, which include premature aging, are caused by defects in proteins called lamins. Zheng and her team, which included Xin Chen of Johns Hopkins University, decided to examine whether lamins would link stem cell niche function to healthy tissue building and maintenance.
Keywords: Asarone Colorectal cancer Lamins Cell senescence Oct-1
Disappearance and reappearance of the nuclear envelope (NE) during cell cycle is controlled by intermediate filament phosphoprotein called lamin. Lamins are an integral part of the nuclear matrix and are apposed to the inner nuclear membrane [7].
Lamins A and C, the products of the LMNA gene, ate nuclear intermediate filament proteins and are the major structural components of the lamina network that underlies and supports the nuclear envelope.
In these proceedings from the January 2004 symposium, researchers describe their work in such areas as the nuclear envelope/lamina complex, interactions between chromatin and the nuclear lamins, and the functions of proteins associated with the inner nuclear envelope membrane.
These disorders and their relationship to LMNA mutations have been reviewed recently {Burke and Stewart (2002)}, and Hutchinson (2002) has reviewed the function of lamins in the nuclear envelope.
The role of isoprenylation in membrane attachment of nuclear lamins. A single point mutation prevents proteolytic cleavage of the lamin A precursor and confers membrane binding properties.