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Related to Leber's congenital amaurosis: Leber's hereditary optic neuropathy


Total loss of vision, especially when occurring without pathological changes to the eye.

[Greek amaurōsis, from amauroun, to make dim, from amauros, dark.]

am′au·rot′ic (-rŏt′ĭk) adj.


(Medicine) pathol blindness, esp when occurring without observable damage to the eye
[C17: via New Latin from Greek: darkening, from amauroun to dim, darken]
amaurotic adj


(ˌæm ɔˈroʊ sɪs)

partial or total loss of sight, esp. in the absence of a gross lesion or injury.
[1650–60; < Greek: darkening, hindrance to sight]
am`au•rot′ic (-ˈrɒt ɪk) adj.


a condition of partial or total blindness, caused by a disease of the optie nerve. — amaurotic, adj.
See also: Blindness
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.amaurosis - partial or total loss of sight without pathology of the eyeamaurosis - partial or total loss of sight without pathology of the eye; caused by disease of optic nerve or retina or brain
vision defect, visual defect, visual disorder, visual impairment - impairment of the sense of sight
References in periodicals archive ?
The lead program in the ophthalmology pipeline, QR-110, is currently in a Phase 1/2 safety and efficacy trial in adult and pediatric patients with Leber's congenital amaurosis 10, due to the p.
Recently, validation and expansion of the platform included positive results in clinical trials in cystic fibrosis and initiating a clinical trial in Leber's congenital amaurosis.
Mutations in RPE65 cause Leber's congenital amaurosis.
Ruben, of Birmingham, has been blind from birth due to a rare condition, Leber's congenital amaurosis.
The product is used to treat nyctalopia, or night blindness, in patients with Leber's congenital amaurosis due to mutations in the RPE65 gene.
Jessica Smith was told she would lose her sight within a year after being diagnosed with rare condition Leber's congenital amaurosis.
However, months later, the pair from Wrexham were dealt the blow that their little girl was born with Leber's congenital amaurosis, a rare inherited eye disease which causes complete blindness.
The UF researchers previously had success pioneering the use of gene therapy in clinical trials to reverse a form of blindness known as Leber's congenital amaurosis.