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Related to Leukotriene antagonists: Leukotriene receptor antagonist


Any of several lipid compounds that contain 20 carbon atoms, are related to prostaglandins, and mediate the inflammatory response.

[leuko(cyte) + triene, a compound containing three double bonds (tri- + -ene).]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Biochemistry) one of a class of products of metabolic conversion of arachidonic acid; the active constituents of slow-reacting substance, responsible for bronchial constriction, contraction of smooth muscle, and inflammatory processes
[C20: from leukocyte, in which they were discovered + triene from the conjugated triene unit that they contain]
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


or leu•co•tri•ene

(ˌlu kəˈtraɪ in)

a lipid, C20H30O3, produced by white blood cells in an immune response to antigens, that contributes to allergic asthma and inflammatory reactions.
[1975–80; leuko- + triene (see tri-, -ene)]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
Asthma medications comprise several drug classes, including leukotriene antagonists and steroid-based inhalers.
Other possible treatments include topical cromolyn sodium and leukotriene antagonists. Mastocytoma lesions that are increasing in size or are very symptomatic despite the treatments listed above may benefit from local immunosuppressants, ultraviolet radiation and psoralen application, or excision.
Inhibitors of proliferation of mesangial cells, for example, leukotriene antagonists, may offer therapeutic options for the treatment of proliferative glomerular diseases [29].
Although using high dose antihistamines and leukotriene antagonists, his CU associated symptoms were not healed.
There is very limited literature regarding the use of leukotriene antagonists in acute attack of bronchial asthma.
Table 1: Drugs primarily used for asthma therapy Category Name of drugs Corticosteroids Budesonide, methyl prednisolone Beta agonists Salbutamol, salmeterol, bambuterol, formoterol Methyl xanthine Doxophylline, etophylline, theophylline Leukotriene antagonists Montelukast Antiistaminics Levocetirizine Anticholinergic Ipratropium bromide, tiotropium bromide Table 2: Distribution of study population according to prescribed individual and combined drugs Antiasthmatic No.
[10] Patients were excluded if they had significant co-morbidities, were receiving oral corticosteroids, LABAs, leukotriene antagonists or theophylline or had undergone an asthma exacerbation or lower respiratory tract infection within the four weeks prior to study entry.
Shepstone et al., "Leukotriene antagonists as first-line or add-on asthma-controller therapy," The New England Journal of Medicine, vol.
Medications commonly used to treat asthma include corticosteroids (inhaled and oral), leukotriene antagonists (Singulair, Accolate, and Zyflo), theophylline, bronchodilators (both short- and long-acting), and xolair (Omalizumab).
Inhibitors of the Th2 inflammatory response (blocking IL-4, IL-5, or leukotriene antagonists) are not as effective in atopic diseases as corticosteroids.