Citrus fruits, like limes, are rich in the compound limonin
, which is easily digestible and has shown progress in fighting several cancers and for cancer chemoprevention (Critical Reviews in Food Science and Nutrition, 2014).
attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway," European Journal of Pharmacology, vol.
Yu, "Simultaneous determination of limonin
, dictamnine, obacunone and fraxinellone in rat plasma by a validated UHPLC-MS/MS and its application to a pharmacokinetic study after oral administration of cortex dictamni extract," Journal of Chromatography B, vol.
Ferulic acid (1.27 mg), naringin (1.97 mg), hesperidin (1.57 mg), neohesperidin (2.03 mg), berberine (2.70 mg), palmatine (2.23 mg), limonin
(1.56 mg), and glycyrrhizic acid (2.83 mg) were weighted, respectively.
Citrus limonoids such as limonin
and nomilin are responsible for the bitter taste of citrus fruits and are characterized by their substituted furan moiety .
Berberine hydrochloride, palmatine hydrochloride, and limonin
reference standards were purchased from the National Institute for the Control of Pharmaceutical and Biological Products (Beijing, China).
Nowadays, phytochemical studies have revealed that limonin
and limonoids exerted pharmacology ability of anticancer [12, 13], antiobesity , anti-inflammatory , and hepatoprotective .
A variety of in Limonin
17-beta-D- (2005) vitro models glucopyranoside, apigenin, scutellarein, kaempferol, rutin trihydrate, neohesperidin, neoeriocitrin, naringenin, naringin, coumarin (bergapten) Miceli et al.
Wink, Inhibition of P-glycoprotein Activity by Limonin
and other Secondary Metabolites from Citrus Species in Human Colon and Leukaemia Cell Lines, Eur.
Two compounds that inhibited IgE production were isolated from Philodendron chinensis and identified as berberine and limonin
. Berberine was more potent and inhibited IgE production by peripheral blood mononuclear cells by 80% at 0.62 pg/mL.
Abstract: In this study was quantified limonin
in ethanol extracts of citrus waste (peels and seeds) of two species (C.
Also, according to the ASPCA Animal Poison Control Center, the peels, fruit, and seeds of citruses such as lemons, oranges, limes, and grapefruits contain varying amounts of citric acid, limonin
, and volatile oils that can cause gastrointestinal irritation and result in vomiting and diarrhea.