The structure of PFPiAs suggests that they would be persistent against biological transformations because of the perfluoroalkyl chains and the stable carbon-phosphorus bonds that link the hydrophobic and
lipophobic perfluoroalkyl groups of the surfactant to the polar head group.
Also, perfluorocarbons are both hydrophobic and
lipophobic, thus, they show high efficacy in protecting a medical device and enhancing its efficiency [25].
However, it is possible that lipophilic and
lipophobic statins may have differential efficacy in decreasing fibrosis progression.
Ideally, the packaging material should be both hydrophobic and
lipophobic to repel both water and fat.
Second-generation antihistamines, being more
lipophobic or hydrophilic, offer the advantages of a lack of central nervous system and anticholinergic side effects such as sedation and dry mouth, which are commonly seen in first-generation antihistamines.
A grease and dirt repellent kitchen coatings called Sigma LTA for
lipophobic technology for acrylics was, for example, launched in the Netherlands in late 2014 and then neighboring Belgium and Germany last year while its introduction in France is planned for the end of this year.
Comments: The FS treatment has both hydrophobic and
lipophobic properties.
Many of these substances show
lipophobic characteristics which could be used for therapeutics diseases neurosensory organs [103].
1 Cetirizine is known to have reduced blood-brain barrier penetration due to its larger mass,
lipophobic properties and increased attraction for peripheral H1 receptors.
As an example application, poly(tetrafluoroethene) is hydrophobic and
lipophobic.
The greater drug penetration enhancing activity of solution may be attributed to the combined effects of both lipophilic and
lipophobic domains of solutions (Yamada et al.
These
lipophobic ("fat-fearing") statins are reluctant to dissolve into cell membranes.
