He further pointed out that previous studies have shown that some FDA-approved drugs inhibit CYP monooxygenases, including Micardis, a blood pressure medication, and Lopid
, which is used to lower cholesterol.
antihyperlipidaemic compounds in rats," IUBMB Life, vol.
Rosenson noted that, in his study, 62% of the HIV-infected patients on a contraindicated statin were taking a protease inhibitor, 29% were on gemfibrozil (Lopid
), and the remaining handful were on other agents posing significant risk of drug interactions, including azole antifungals, calcium channel blockers, or cobicistat (Tybost).
The fibric acid derivatives subclass includes fenofibrate (Tricor, Lofibra) and gemfibrozil (Lopid
On the other hand, Lopid
(gemfibrozil) and Atromid (clofibrate) are reported to cause sleepiness.
This includes a fibrate such as gemfibrozil (Lopid
) or niacin.
greater than 500 mg/dL) also may be prescribed fibrate drugs such as fenofibric acid (Tricor) and gem-fibrozil (Lopid
) or prescription-strength omega-3 fatty acids.
They include niacin or nicotinic acid; statins, such as atorvastatin (Lipitor), simvastatin (Zocor), or rosuvastatin (Crestor); fibrates, such as fenofibrate (Lofibra, TriCor) and gemfibrozil (Lopid
); and omega-3 fatty acid supplements (either in the prescription form, Lovaza, or as over-the-counter supplements).
(39) There are several medications that reduce triglycerides, including fibrates, such as fenofibrate (Lofibra, TriCor) and gemfibrozil (Lopid
); niacin (Niaspan); and ethyl esters of omega-3 fatty acids known as Lovaza.
Another side effect, hypertriglyceridemia, responds to fish oil or 5 the fibrate drug gemfibrozil (Lopid
Like niacin, fenofibrates, such as gemfibrozil (Lopid
), raise HDL, but they also lower triglycerides, and the double effect can reduce the risk of major cardiovascular events by as much as 10 percent and heart attacks by 13 percent, concluded Australian researchers.