lipa

(redirected from Lysosomal Acid Lipase)
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li·pa

 (lē′pə)
n. pl. lipa
A Croatian unit of currency equal to 1/100 of the kuna.

[Serbo-Croatian.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

lipa

(ˈliːpə)
n, pl lipa
(Currencies) a monetary unit of Croatia worth one hundredth of a kuna
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

li•pa

(ˈli pə)
n., pl. -pa.
a monetary unit of Croatia.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
In December 2015, the FDA approved an enzyme replacement therapy Kanuma that can be used to treat adult and pediatric patients suffering from lysosomal acid lipase deficiency, a metabolic disorder that causes problems with the breakdown and use of fats and cholesterol in the body.
A novel variant of lysosomal acid lipase in cholesteryl ester storage disease associated with mild phenotype and improvement on lovastatin.
Alexion also has two innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia and lysosomal acid lipase deficiency (LAL-D).
Alexion also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia (HPP) and lysosomal acid lipase deficiency (LAL-D).
The company also has two highly innovative enzyme replacement therapies for patients with life-threatening and ultra-rare metabolic disorders, hypophosphatasia and lysosomal acid lipase deficiency (LAL-D).
Lysosomal acid lipase deficiency (LAL-D) is an autosomal recessive disorder characterized by the accumulation of triglycerides and cholesteryl esters in the lysosome.
Other enzyme studies of interest include LCAT activity in the setting of low HDL cholesterol, and lysosomal acid lipase in Wolman disease and CE storage disease.
Lysosomal acid lipase (LAL) [3] deficiency is an autosomal recessive lysosomal storage disease with 2 distinct phenotypes: a severe infantile form known as Wolman disease and a milder, later-onset form referred to as cholesterol ester storage disease (1).
In 2015 the US FDA has also approved genetically modified chickens that can produce eggs that can treat lysosomal acid lipase deficiency-a rare genetic condition that prevents the body from breaking down fatty molecules inside cells.
Lysosomal acid lipase (LAL) deficiency (cholesteryl ester storage disease/Wolman disease; Online Mendelian Inheritance in Man database #278000) is an autosomal recessive lysosomal storage disorder caused by mutations in the LIPA gene that reduce LAL activity [1].
Interestingly, the activity of Lipa (lysosomal acid lipase), another enzyme that uses fatty material as a substrate, is increased in IL-4-stimulated macrophages [46].
(1) It is a rare autosomal recessive inborn error of lipid metabolism (the gene for this enzyme is located on chromosome 10q23.2-q23.3.2) characterized by lysosomal acid lipase deficiency.

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