Gene symbols: ALPI, intestinal-type alkaline phosphatase; CHGA, chromogranin A; DEFA5, defensin [alpha] 5; FFA4R, free fatty acid receptor 4; GAPDH, glyceraldehyde- 3-phosphate dehydrogenase; LGR5, leucin-rich repeat-containing G-protein-couple receptor 5; LYZ, lysosyme; MKI67
, marker of proliferation Ki-67; MUC2, mucin 2; SI, sucrose isomaltase; SYP, synaptophysin; TFF3, trefoil factor 3.
Three sections per uterus were stained for histological analysis with antibodies to GR (1:500; Cell Signaling Technologies) or MKi67
(1:400; Cell Signaling Technologies) overnight at 4[degrees]C (see Table S2).
Han et al., "Genome-wide association study of mki67
expression and its clinical implications in hbv-related hepatocellular carcinoma in southern china," in Proceedings of the Cellular Physiology Biochemistry International Journal of Experimental Cellular Physiology Biochemistry Pharmacology, vol.
Conversely, we found a mild inverse correlation of CXCR4 and CXCL12 with MKI67
(rs = -0.1262; rs = -0.2076, resp.), thus confirming the lack of association between the CXCR4/CXCL12 axis and proliferation in luminal B BC (Figures 4(a) and 4(b)).
As reported in Table 2, 14 genes (KRT19, FLT1, EGER, EPCAM, MET, PGR, CD24, KIT, PLAU, ALDH1A1, CTSD, MKI67
, TWIST1, and ERBB2) were evaluated as significantly differentially expressed in the tested sample cohorts between CTC+ and CTC- samples.
Antigen Ki67 is a nuclear protein, encoded by MKI67
gene that is mapped at 10q26.2.
This group was marked by high activation of the cell proliferation marker Mki67
. In addition, this group is comprised of interferon-induced GTPases such as Gbp6 and Gbp10, which are involved in the innate response to protect against a bacterial infection  and Iigp1.
The expression of other genes from the cell cycle functional group was altered: APC (-3.79), CCND1 (-1.90), CCNE1 (-2.38), MKI67
(-1.51), MYC (2.04) and TP53 (2.05).
After 3 injections of docetaxel (once a week), 7 mice were sacrificed to analyze MKI67
gene and protein expressions and the rest were monitored for diet consumption, tumor growth and survival rates.
(25) The authors found a strong correlation between FDG uptake and mitotic counts; and the percentage of cells positive for the Ki-67 protein, which is a product of the MKI67
gene, and nuclear grade.
Among the 1485 DEGs, neuroendocrine-associated genes SYP (Syn; FC=1.5, FDR = 0.04), CHGA (CgA; FC = 3.02, FDR=0.04), NCAM1 (CD56; FC=18.10, FDR=0.006), ASCL1 (FC=619.23, FDR=0.0005), and GRP (FC=5.33, FDR= 0.03) and proliferation-associated genes MKI67
(Ki-67; FC=9.35, FDR=0.007) and PCNA (FC=4.20, FDR= 0.006) were overexpressed.
E2 had a significant effect on the expression of genes associated with cell division (Top2a, Mki67
, Ccnbl, Ccnb2; Figure 5A) and cytokinesis (Kifll, Kf2c, Kif18a; Figure 5B).