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Matrix metalloproteinases (MMP) 1 and MMP10 but not MMP12 are potential oral cancer markers.
On the other hand, we found a significant decrease in MMP12 in the placental tissue of GDM group [Figure 1]a.
ELANE which encodes neutrophil elastase, together with matrix metalloproteinase 12 (MMP12), has been reported in the development cystic fibrosis in lungs .
The incomplete degradation of 3D/FN and 3D/LN structures may reflect the low or lack of expression of MMPs specific for these ECM proteins, namely, MMP7, MMP10, MMP11, MMP14, and MMP15 for LN and MMP7, MMP10, MMP11, MMP12, MMP14, and MMP15 for FN.
Activation of MMP-7 has been shown to inactivate AAT, thus further augmenting the effect of free NE activity , whereas the release and activation of MMP12 is involved in alveolar wall destruction .
They produce matrix metalloproteinases like matrix metalloproteinase-2 (MMP2), matrix metalloproteinase-9 (MMP9), matrix metalloproteinase-12 (MMP12), and matrix metalloproteinase-19 (MMP19) [42, 68], to degrade matrix macromolecules, that is, collagen, one of the most important components of ECM.
PPAR[delta] activates PPRE-containing genes associated with metabolism (Olah, Ptgs2, Pla2, and Pld), invasion (Mmp12, Klk6), and inflammation (S100a8/9, Saa1/2/3).
Liu et al., "Macrophage metalloelastase (MMP12) regulates adipose tissue expansion, insulin sensitivity, and expression of inducible nitric oxide synthase," Endocrinology, vol.
Tesfaigzi et al., "MMP12, lung function, and COPD in high-risk populations," The New England Journal of Medicine, vol.
miRNA ID NOG p value TFP p value miR-145-5p 1 1.66E--02 0.67 2.98E--08 miR-204-5p 5 1.78E--15 0.13 1.05E--02 miR-182-5p 2 1.80E--08 0.20 4.34E--04 miR-567 1 1.66E--02 0.25 4.61E--04 miR-141-3p 2 1.80E--08 0.14 2.05E--03 miR-454-3p 2 1.80E--08 0.11 4.64E--02 miR-590-3p 5 1.78E--15 0.13 2.33E--03 miR-338-3p 2 1.80E--08 0.25 4.61E--04 miR-139-5p 1 1.66E--02 1.00 1.49E--08 miRNA ID Whole target genes miR-145-5p MMP12; ZFP36; KLF4 miR-204-5p DPYSL2; EMP1; SPDEF; LMO7; SLC1A1; ALPL; MMP9; FRAS1 miR-182-5p CAMK2N1; ZFP36; UBE2T; LPHN2; RGS17.
Due to structural and substrate specificity, MMPs are currently divided into seven classes: collagenases (MMP1, MMP8, MMP13, and MMP18), gelatinases (MMP2 and MMP9), stromelysins (MMP3, MMP10), stromelysin like (MMP11 and MMP12), matrilysins (MMP7 and MMP26), membrane type (MMP14, MMP15, MMP16, MMP17, MMP24, and MMP25), and others (MMP19, MMP20, MMP21, MMP22, MMP23, MMP27, and MMP28) [18, 27, 28].
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