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A folate antagonist, C20H22N8O5, that inhibits DNA synthesis and is used to treat psoriasis, certain cancers, and some inflammatory diseases such as rheumatoid arthritis. It is sometimes used in combination with misoprostol to induce abortion in early pregnancy.

[methotre- (probably shortening and alteration of methylaminopterin, one of its chemical names : methyl + aminopterin) + perhaps (o)x(y)- + -ate.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌmɛθəʊˈtrɛkseɪt; ˌmiːθəʊ-)
(Pharmacology) an antimetabolite drug used in the treatment of certain cancers. Formula: C20H22N8O5
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌmɛθ oʊˈtrɛk seɪt)

a toxic folic acid analogue, C20H22N8O5, that inhibits cellular reproduction and is used in the treatment of psoriasis and certain cancers.
[1950–55; metho (xy)- + trexate, of unclear derivation]
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.methotrexate - toxic antimetabolite that limits cellular reproduction by acting as an antagonist to folic acid; used to treat certain cancers and psoriasis and rheumatoid arthritis
antimetabolite - an antineoplastic drug that inhibits the utilization of a metabolite
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


n metotrexato, metotrexate m
English-Spanish/Spanish-English Medical Dictionary Copyright © 2006 by The McGraw-Hill Companies, Inc. All rights reserved.
References in periodicals archive ?
Os medicamentos incluidos na analise foram Adalimumabe (ADA); Etanercepte (ETA); Infliximabe (INF); Metotrexato (MTX); Azatioprina (AZA); Ciclosporina (CIC); Cloroquina (CLO); Hidroxicloroquina (HID); Leflunomida (LEF) e Sulfassalazina (SUL).
injection the rats (n = 4/group) were treated 4x (d0, d7, d14, and d21) either with saline (500[micro]L, intraperitoneal (i.p.) injection) or with MTX (VU University Medical Centers' Pharmacy) (i.p.) at 1.0 mg/kg.
Twelve patients discontinued treatment due to diarrhea, severe oral ulcers, markedly raised ALT; (Each affecting 2 patients) and severe vomiting, abscess, MTX Induced pneumonitis, severe chest infection (each affecting 1 patient).
[beta]-hCG, RFT, LFT and blood group were done and on Di single dose of 50 mg/[m.sup.2] Mtx was administered.
MTX is an anti-proliferative, immunosuppressive and anti-inflammatory agent used in cancer chemotherapy and other diseases such as rheumatoid arthritis and psoriasis.
LCV is used to selectively "rescue" the cells from the adverse effects caused by methotrexate (MTX)blocks the activation of folic acid and inhibits nucleic acid synthesis.
Triple therapy is considerably less costly than the MTX + TNFi therapy, but it involves a more complicated regimen of multiple pills taken daily.
The trial, which lasted 12 months and enrolled about 1,150 patients, consisted of three comparisons, which found that Xeljaz plus MTX met its primary endpoint in demonstrating non-inferiority versus Humira plus MTX.
Sixteen rats were given a single dose of 20 mg/kg MTX to induce liver injury.
Despite some disadvantages, local MTX injection is less invasive and easier to administer compared to surgical treatments [7].