Expression of gastric mucin MUC5AC
and gastric transcription factor SOX2 in ampulla of Vater adenocarcinoma: comparison between expression patterns and histologic subtypes.
pylori provides identification of intestinal metaplasia, which is characterized by reduced expression of gastric mucins (MUC5AC
and MUC6) and de novo expression of MUC2 (20).
Immunohistochemistry (IHC): EMA, CK7, ER, PR, MUC5AC
, GCDFP15, Mammaglobin, CK20--positive in tumor cells.
El subtipo pancreatobiliar tipicamente muestra expresion CK7 y MUC1, mientras que el subtipo gastrico suele expresar MUC5AC
y MUC6, el intestinal expresa MUC2, CDX2 y CK20, y el oncocitico, MUC1.
In SRCC, accumulation of mucins like MUC1, MUC2, MUC4, MUC5AC
, MUC6 results in large vacuoles, which could therefore play a role in carcinogenesis.
In vapers, cytochrome P450 family 1 subfamily B member 1, mucin 5 AC (MUC5AC
), and MUC4 levels were increased.
Interleukin-1 beta and tumor necrosis factor-alpha induce MUC5AC
overexpression through a mechanism involving ERK/p38 mitogen-activated protein kinases-MSK1-CREB activation in human airway epithelial cells.
Appendix goblet cells secrete MUC2 and MUC5AC
MUC2 measurement is a specific indicator in the case of psesudomyxoma peritonei related to appendix GCC (18).
During this process, mucus is propelled from the airways toward the throat by the continuous ciliary beating of ciliated cells. MUC5B and MUC5AC
, the main mucins of the mucus gel, are mainly produced by the goblet cells of the surface epithelium and by the submucosal glands. Moreover, it has been reported that club cells can produce MUC5B in the lower airways. A second constitutive defense lining, the periciliary layer, separates the luminal airway epithelium and mucin gel.
Effect of glycosides based standardized fenugreek seed extract in bleomycin-induced pulmonary fibrosis in rats: Decisive role of Bax, Nrf2, NF-KB, Muc5ac
, TNF-[alpha] and IL-1[beta].
Based on the structure and function of a molecule, mucin is subdivided into 3 categories: membrane-bound mucins (MUC1, MUC3 MUC4, MUC12, MUC16, MUC17), gel-forming (secreted) mucins (MUC2, MUC5AC
, MUC5B, MUC6, MUC19), and soluble mucin (MUC7).
Joshi et al., "Immunohistochemical study of MUC1, MUC2 and MUC5AC
expression in primary breast carcinoma," Journal of Clinical and Diagnostic Research, vol.