They were previously described as the May-Hegglin anomaly, Fechtner syndrome, Sebastian syndrome, and Epstein syndrome, yet they all result from autosomal dominant mutations in the cytoskeletal protein MYH9
. (10) The type of mutation and area of the protein affected correlates with the phenotype, both at the ultrastructural level (type of inclusions seen) and the clinical phenotype (type of end organ damage associated); hence, molecular characterization can be an important tool in prognostication and follow-up of the affected families.
(9) identified 284 DEGs correlated with AS (such as MYH9
, BCL11B and CD4), and detected the pathway for immune response regulation.
Anti-SMMHCs types 1 and 2 rabbit polyclonal IgG (BT-562) was from Biomedical Technologies Inc., Stoughton, MA, and anti-nonmuscle myosin heavy chain IIA (NMMHCIIA) rabbit polyclonal IgG (MYH9
) was from Sigma-Aldrich.
gene located on chromosome 22 q12.3-13.2 encodes nonmuscle myosin IIA.
MYH14, also known as nonmuscle II heavy chain (NMHCII-C), together with two other nonmuscle chains (MYH9
and MYH10), is a member of the myosin family, which have been implicated in many motile processes such as ion-channel gating, organelle translocation, and cytoskeleton rearrangement [21, 22].
Thus, the coexpression of MYH9
, ZNRD1, and other disease pathway genes suggests probable AIDS complicating diseases.
It appears that HIVAN occurs in the setting of specific host genes and it has been widely accepted that the gene encoding a non-myosin A heavy chain (MYH9
) is associated with FGS, HIVAN, and end-stage kidney disease (ESKD) due to hypertension in individuals of African descent [23, 24].
Some other research revealed that MYL12A and MYL12B are crucial for maintenance of the stability of MYH9
, MYH10, and MYL6, which leads to normal cell actomyosin function .
We observed positive correlations (absolute value > 0.15) with all ARGs, including PPIA (0.42), ZNRD1 (0.37), MYH9
(0.36), TSG101 (0.31), IDH1 (0.28), TRIM5a (0.17), and CUL5 (0.15), but not GML (-0.17) and NCOR2 (-0.31).
Another potential candidate for usage as a urinary biomarker of podocyte injury is myosin heavy chain 9 (MYH9
), which is a subunit of a larger protein named nonmuscle myosin IIA .
Today HIV-associated nephropathy (HIVAN) is a main cause of end-stage renal disease in HIV-infected African-Americans, and it is likely to be a result of a recently identified genetic predisposition based on polymorphisms of the myosin heavy-chain 9 (MYH9