Machupo virus


Also found in: Thesaurus, Medical, Wikipedia.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.Machupo virus - the RNA virus that causes Bolivian hemorrhagic feverMachupo virus - the RNA virus that causes Bolivian hemorrhagic fever; carried by rats and mice
arenavirus - animal viruses belonging to the family Arenaviridae
Arenaviridae - a family of arborviruses carried by arthropods
Mentioned in ?
References in periodicals archive ?
We generated pseudotypes as described (11) by using 25 [micro]g EBOV-GP expression plasmid or 30 [micro]g Machupo virus glycoprotein (MACV-GP) expression plasmid and 10 pg pNL-Luc or pNL-Ren.
Outside of the the Filoviridae, there are the Arenaviridae (Lassa fever and more exceptionally the Junin and Machupo virus), and the Bunyaviridae (Crimean-Congo hemorrhagic fever).
In 1963, Machupo virus was isolated in the remote savannas of Bolivia.
But over a year, the team collected 10,000 fleas, mites, ticks and mosquitoes; none were carrying the Machupo virus, as it became known.
Calomys callosus (or a close relative, see Salazar-Bravo et al., 2002) was identified as the reservoir for Machupo virus, the etiological agent for Bolivian Hemorrhagic Fever (Johnson et al., 1966).
In July 1934, an outbreak of Bolivian hemorrhagic fever (BHF), which is caused by Machupo virus, began in northeastern Bolivia.
Tacaribe serocomplex viruses (family Arenaviridae, genus Arenavirus) comprise Bear Canyon virus, Tamiami virus, and Whitewater Arroyo virus in the United States; Tacaribe virus (TCRV) on Trinidad; Chapare virus (CHPV) and Machupo virus (MACV) in Bolivia; Guanarito virus (GTOV) in Venezuela; Junin virus (JUNV) in Argentina; Sabia virus (SABV) in Brazil; and 9 other species (1).
These agents are members of several virus groups, including filoviruses (Ebola virus, Marburg virus), Old World arenaviruses (Lassa virus, Lujo virus), New World arenaviruses (Machupo virus, Junin virus, Sabia virus, Guanarito virus, Chapare virus), flaviviruses (Omsk hemorrhagic fever virus, Kyasanur Forest disease virus), and bunyaviruses (Crimean-Congo hemorrhagic fever virus, Rift Valley fever virus) (1).
However, it was not until 1963 that the etiologic agent, Machupo virus, was isolated from the spleen of a patient who died from this disease (1).