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The process of self-digestion by a cell through the action of enzymes originating within the same cell.


(ɔːˈtɒfədʒɪ) or


the consumption of one's own tissue by biting oneself

autophagy, autophagia

Medicine. 1. the eating of one’s own body.
2. the nutrition of the body by its own tissues, as in dieting. — autophagous, adj.
See also: Food and Nutrition
References in periodicals archive ?
5,8] Macroautophagy is generally referred as "autophagy" due to the limited data for the other forms.
Loss of mTOR-dependent macroautophagy causes autistic-like synaptic pruning deficits.
2015) Fasting activates macroautophagy in neurons of Alzheimer's disease mouse model but is insufficient to degrade amyloid-beta.
Ceramide-mediated macroautophagy involves inhibition of protein kinase B and up-regulation of beclin 1.
Autophagy is divided into three types, which are microautophagy, chaperone-mediated autophagy, and macroautophagy (Liu et al.
Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy in vascular endothelial cells.
A53T human alpha-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy defects preceding dopamine neuron degeneration.
Macroautophagy inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization.
Maltese, "Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking," Journal of Cell Science, vol.
Simultaneously, owing to stresses in the local microenvironment, macroautophagy and chaperone-mediated autophagy destroy the cells' internal structures with the activity of lysosomes.
Overview of macroautophagy regulation in mammalian cells.