is generally referred as "autophagy" due to the limited data for the other forms.
- A novel beta-amyloid peptide-generating pathway activated in Alzheimer's disease.
Loss of mTOR-dependent macroautophagy
causes autistic-like synaptic pruning deficits.
2015) Fasting activates macroautophagy
in neurons of Alzheimer's disease mouse model but is insufficient to degrade amyloid-beta.
involves inhibition of protein kinase B and up-regulation of beclin 1.
Autophagy is divided into three types, which are microautophagy, chaperone-mediated autophagy, and macroautophagy
(Liu et al.
Pterostilbene, a natural small-molecular compound, promotes cytoprotective macroautophagy
in vascular endothelial cells.
A53T human alpha-synuclein overexpression in transgenic mice induces pervasive mitochondria macroautophagy
defects preceding dopamine neuron degeneration.
inhibition sensitizes tamoxifen-resistant breast cancer cells and enhances mitochondrial depolarization.
Maltese, "Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy
versus endocytosis and lysosomal enzyme trafficking," Journal of Cell Science, vol.
Simultaneously, owing to stresses in the local microenvironment, macroautophagy
and chaperone-mediated autophagy destroy the cells' internal structures with the activity of lysosomes.
Overview of macroautophagy
regulation in mammalian cells.