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The process of self-digestion by a cell through the action of enzymes originating within the same cell.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ɔːˈtɒfədʒɪ) or


the consumption of one's own tissue by biting oneself
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014

autophagy, autophagia

Medicine. 1. the eating of one’s own body.
2. the nutrition of the body by its own tissues, as in dieting. — autophagous, adj.
See also: Food and Nutrition
-Ologies & -Isms. Copyright 2008 The Gale Group, Inc. All rights reserved.
References in periodicals archive ?
Autophagy is involved in both healthy and diseased liver [13-15] and is an intracellular self-digesting pathway, which can be divided into three main types: chaperone-mediated autophagy, microautophagy, and macroautophagy [16, 17].
LC3, a mammalian homolog of yeast Atg8, is known as a marker for macroautophagy. LC3-I is localized in cytoplasm while LC3-II (the phosphatidylethanolamine-conjugated form of LC3-I) exists in the membranes of the autophagosome.
On the basis of different ways of transporting intracellular constituents to lysosomes, autophagy is divided into three types: macroautophagy, microautophagy, and chaperonemediated autophagy [12].
There are three main types of autophagy: macroautophagy, microautophagy, and chaperone mediated autophagy.
The most prevalent form of autophagy is macroautophagy, usually simply referred to as autophagy, which is characterised by membranes that gradually grow in size to generate double membrane-structures (i.e., autophagosomes).
(70) Recently, it was reported that LDs are substrates for autophagy ("macroautophagy"), a lysosomal pathway by which intracellular organelles and proteins are degraded to supply the cell with energy and maintain cellular homeostasis.
Maltese, "Functional specificity of the mammalian Beclin-Vps34 PI 3-kinase complex in macroautophagy versus endocytosis and lysosomal enzyme trafficking," Journal of Cell Science, vol.
Distinct classes of phosphatidylinositol 3'-kinases are involved in signaling pathways that control macroautophagy in HT-29 cells.
The only known mechanism whereby mitochondria are turned over is through macroautophagy. The efficiency of this process declines with advancing age, which may play a critical role in heart senescence and age-related cardiovascular disease.
The shuttling of intracellular antigens onto MHC class II by macroautophagy was first obtained in several cell culture models [71-75].
Kim et al., "Heme oxygenase-1 inhibits renal tubular macroautophagy in acute kidney injury," Journal of the American Society of Nephrology, vol.
Based on morphological and mechanistic characteristics, three forms of autophagy are recognized to date: macroautophagy, microautophagy, and chaperonemediated autophagy (CMA) [138, 173].