The collaboration, established in December 2009, utilized Trartzyme's chemistry technology, Macrocyclic Template Chemistry (MATCH), for the discovery of novel active macrocycles
against a range of biological targets with high potency and selectivity, as well as high oral availability, good tissue and cell permeability.
TOWARDS NOVEL SHAPE-PERSISTENT BENZOICICINNOLINE-ETHYNYLENE MACROCYCLES
After introducing the paradigm, the book covers methodology useful to diversity-oriented synthesis including multicomponent and "domino" strategies, cycloadditions, phosphine organocatalysis, peptidomimetics, solid-phase synthesis, and macrocycles
. The remainder of the book discusses the conceptual aspects of the resulting libraries--first their organization and biological correspondence, then screening methods and applications to other areas of research.
van Caemelbecke, "Electrochemistry of porphyrins and related macrocycles
," Journal of Solid State Electrochemistry, vol.
Herman et al., "Potentiometric and spectroscopic study of copper(II) and nickel(II) complexes of trans-dioxopentaaza macrocycles
in aqueous solution," Journal of the Chemical Society, Dalton Transactions, no.
 V Bohmer, "Calixarenes, macrocycles
with (almost) unlimited possibilities," Angewandte Chemie (International Edition), vol.
Hameed, "Divalent, cobalt, nickel, copper and zinc complexes of tetraaza macrocycles
bearing polyamide groups: synthesis and characterization," Polyhedron, vol.
Mallik, "Simple synthesis of a new family of 22- to 28-membered macrocycles
containing two chalcone moieties," Arkivoc, vol.
It was observed that the two macrocycles
formed a dimer sandwiching a pair of chloride anions.
In particular, his group has developed new methods for the synthesis of planar chiral macrocycles
and novel olefin metathesis catalysts for the formation of helicenes.
Four transgressive-regressive macrocycles
(= sequences) have been described for the northern Baltic Ordovician succession (Nestor & Einasto 1997).
A variety of reducing systems are available to carry out reduction that includes NaB[H.sub.4.sup.4], Cu, Ni, Co, complexes , and macrocycles