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1. A cyclic macromolecule.
2. A molecule or portion of a molecule in which atoms, usually ten or more, are connected in a ring.

mac′ro·cyc′lic (-sĭk′lĭk) adj.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˌmækrəʊˈsɪklɪk; ˌmækrəʊˈsaɪklɪk)
(Chemistry) containing or relating to a macrocycle
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌmæk roʊˈsaɪ klɪk, -ˈsɪk lɪk)

having a ring structure consisting of more than 12 atoms.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
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References in periodicals archive ?
The collaboration, established in December 2009, utilized Trartzyme's chemistry technology, Macrocyclic Template Chemistry (MATCH), for the discovery of novel active macrocycles against a range of biological targets with high potency and selectivity, as well as high oral availability, good tissue and cell permeability.
After introducing the paradigm, the book covers methodology useful to diversity-oriented synthesis including multicomponent and "domino" strategies, cycloadditions, phosphine organocatalysis, peptidomimetics, solid-phase synthesis, and macrocycles. The remainder of the book discusses the conceptual aspects of the resulting libraries--first their organization and biological correspondence, then screening methods and applications to other areas of research.
van Caemelbecke, "Electrochemistry of porphyrins and related macrocycles," Journal of Solid State Electrochemistry, vol.
Herman et al., "Potentiometric and spectroscopic study of copper(II) and nickel(II) complexes of trans-dioxopentaaza macrocycles in aqueous solution," Journal of the Chemical Society, Dalton Transactions, no.
[6] V Bohmer, "Calixarenes, macrocycles with (almost) unlimited possibilities," Angewandte Chemie (International Edition), vol.
Hameed, "Divalent, cobalt, nickel, copper and zinc complexes of tetraaza macrocycles bearing polyamide groups: synthesis and characterization," Polyhedron, vol.
Mallik, "Simple synthesis of a new family of 22- to 28-membered macrocycles containing two chalcone moieties," Arkivoc, vol.
It was observed that the two macrocycles formed a dimer sandwiching a pair of chloride anions.
In particular, his group has developed new methods for the synthesis of planar chiral macrocycles and novel olefin metathesis catalysts for the formation of helicenes.
Four transgressive-regressive macrocycles (= sequences) have been described for the northern Baltic Ordovician succession (Nestor & Einasto 1997).
A variety of reducing systems are available to carry out reduction that includes NaB[H.sub.4.sup.4], Cu, Ni, Co, complexes [5], and macrocycles [6].