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1. A cyclic macromolecule.
2. A molecule or portion of a molecule in which atoms, usually ten or more, are connected in a ring.

mac′ro·cyc′lic (-sĭk′lĭk) adj.


(ˌmækrəʊˈsɪklɪk; ˌmækrəʊˈsaɪklɪk)
(Chemistry) containing or relating to a macrocycle


(ˌmæk roʊˈsaɪ klɪk, -ˈsɪk lɪk)

having a ring structure consisting of more than 12 atoms.
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References in periodicals archive ?
Fidaxomicin is the first in a new class of macrocyclic antibiotics and lately been licensed by the European Medicines Agency (EMA).
According to the company, Ulimorelin, which is a macrocyclic agonist of the hormone ghrelin, is under clinical development as LP101 for the treatment of EFI as well as for other disorders affecting critically ill patients in the Intensive Care Unit (ICU).
Cypralis and Gilead Sciences have agreed that Cypralis will have exclusive development and commercialization rights to certain macrocyclic inhibitors of peptide bond isomerases, in all fields except for oncology and virology.
Our PDPS technology allows for the creation of macrocyclic peptide libraries of almost limitless chemical diversity that can then be selected against targets of interest, leading to the rapid identification of highly active and selective hits against difficult-to-address targets.
Calixarenes are macrocyclic oligomers synthesized from the condensation of phenol and formaldehyde in basic environment [9].
Stachybotrys is known for its production of the highly toxic macrocyclic trichothecene mycotoxins, which can be extremely neurotoxic.
For now, fidaxomicin, a narrow spectrum macrocyclic antibiotic, may be appropriate for those at high risk for relapse and/or those requiring concomitant antibiotics--but its high price tag may be prohibitive.
Of the two types of gadolinium, linear and macrocyclic, the PRAC-EMA recommended the former type no longer be marketed as it was associated with greater retention of the GBCA (FDA, 2017).
Macrocyclic lactone (3-ML) injectables are licensed to treat sheep scab and these will also target gastrointestinal worms.
Dung removal by dung beetles (Coleoptera: Scarabaeidae) and macrocyclic lactone use on cattle ranches of Yucatan, Mexico
The resulting macrocyclic molecules are stable in solution, can bind transition metals ions and host small molecules.
It covers the historical background of macrocyclic compounds, then the fundamental properties, characteristic features, and advantages of pillararenes, such as their high yield synthesis and highly symmetrical structures, versatile functionality, conformation, planar chirality, host-guest properties, and assembled structures, and applications to supramolecular polymers, interlocked molecules, supramolecular assemblies, hybrid materials, and biomedical applications, as well as pillararene-related macrocyclic compounds.