Also found in: Medical, Encyclopedia, Wikipedia.
(Biology) biology an abnormally great change in the characteristics of a population of animals or plants over relatively few successive generations: hypothesized in the evolutionary theory of punctuated equilibrium, which states that such populations remain stable for long periods of time and evolve into new species through sudden, drastic mutations
[C20: from macro- + mutation]
mac•ro•mu•ta•tion(ˌmæk roʊ myuˈteɪ ʃən)
a mutation that results in a profound change in an organism, as a change in a regulatory gene that controls the expression of many structural genes.