Intra-Cellular Therapiesannounced top-line results from two Phase 3 clinical trials evaluating lumateperone as monotherapy in the treatment of major depressive episodes
associated with Bipolar I or Bipolar II disorder.
In the stress-diathesis model for suicidal behavior, stress from major depressive episodes
and life events contributes to the patient's perception of stress, which in turn contributes to that patient's response to stress.
Although perimenopausal women are more susceptible to the development of depressive symptoms and major depressive episodes
(MDE), there is a lack of consensus regarding how to evaluate and treat depression in women during the menopausal transition and postmenopausal period.
Lithium's emerging role in the treatment of refractory major depressive episodes
: augmentation of antidepressants.
During that period, 7.1% of mothers suffered from major depressive episodes
.1 In Pakistan, extensive data on the prevalence of perinatal depression is not available.
If no items from criterion C are present, six of the following nine criteria are needed: 1) hyperthymic personality (at baseline, nondepressed state); 2) recurrent major depressive episode
(>3); 3) brief major depressive episodes
(on average, <3 months); 4) atypical depressive features (increased sleep or appetite); 5) psychotic major depressive episode
; 6) early age at onset of major depressive episode
(before age 25); 7) postpartum depression; 8) antidepressant tolerance ("wearoff," acute but not prophylactic response); 9) lack of response to >3 antidepressant treatment trials (Ghaemi, Hsu et al.
Depression, by its clinical nature, is prone to recur with moderate to severe major depressive episodes
often needing hospitalization for treatment, stabilization and risk management (2-3).
There was significant increase in the national annual prevalence of major depressive episodes
among adolescents age 12 to 17, which rose from 8.2% in 2011 to 12.5% in 2015.
An estimated 15.7 million Americans had major depressive episodes
and 9.3 million seriously considered suicide.
However, since the start of this decade there have been more suicides, more adolescents with major depressive episodes
, and fewer people who had a dental visit in the past year.