mast cell

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mast cell

n.
A cell produced in bone marrow that functions in allergic reactions and other inflammatory and immune responses by releasing substances such as histamine and cytokines and by directly killing pathogens. Mast cells are found chiefly in connective tissue and contain basophilic granules.

[Partial translation of German Mastzelle, well-fed cell (from an early view that the granules were from phagocytosis) : Mast, food, mast (from Middle High German, from Old High German) + Zelle, cell.]

mast cell

n
(Biology) a type of granular basophil cell in connective tissue that releases heparin, histamine, and serotonin during inflammation and allergic reactions
[C19: from mast2, on the model of German Mastzelle]

mast′ cell`


n.
a large granular cell, common in connective tissue, that produces heparin, histamine, and serotonin.
[1885–90; partial translation of German Mastzelle=Mast mast2 + Zelle cell]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.mast cell - a large connective tissue cell that contains histamine and heparin and serotonin which are released in allergic reactions or in response to injury or inflammation
connective tissue - tissue of mesodermal origin consisting of e.g. collagen fibroblasts and fatty cells; supports organs and fills spaces between them and forms tendons and ligaments
somatic cell, vegetative cell - any of the cells of a plant or animal except the reproductive cells; a cell that does not participate in the production of gametes; "somatic cells are produced from preexisting cells";
References in periodicals archive ?
It turned out that, in allergic CD, keratinocytes secrete proinflammatory cytokines and chemokines that activate epidermal Langerhans cells and dermal vascular endothelial cells, which also express adhesion molecules and enable extravasation of the sensitized T cells (CD8, Tr1), mastocytes, basophils and immunocytes (19,20).
Neurons and mastocytes dump serotonin into my bloodstream.
Advanced GCTs were associated with decreased T-cell and NK-cell signatures, while T-regs, mastocytes, and macrophages proved to be activated in patients with advanced stage disease.
This may reflect the process, the course of which starts with cellular-endothelial adhesion changes in mucosal microcirculation, facilitating transmigration of T and B lymphocytes from the vessels to the inflamed tissues, and thus aggregation of cells within the tissue, mastocytes, macrophages, eosinophils, and activated neutrophils is also included [29, 56].
have reported the secretion of exosomes from intestinal epithelial cells, fibroblasts, mastocytes, antigen presenting cells, platelets, hepatocytes, and lymphocyte [73].
Caption: Figure 2: Effects of alcohol and high-fat diet on the total amount of cells (a), number of mastocytes (b), and mast cells in the scar tissue of HF + AL (c) in skin wounds of Wistar rats.
Biopsy specimens of pericarotid tissues and carotid adventitia revealed nonspecific chronic inflammation with proliferation of fibroblasts, lymphocytes, mastocytes, and eosinophils, without granuloma formation and without evidence of active infection [14, 15].
Ozone has a potential to limit the inflammatory processes through the reduction of proliferation of neutrophils and mastocytes, impeding release of acute phase proteins, increasing concentration of prostacyclin 6-keto-PGF1[alpha], and decreasing the concentration of prostacyclin PGF2[alpha], which results from the effect of oxygen radicals on arachidonic acid.
Thus, in the skin, the immediate inflammatory answer to stress involves the release of neuropeptides and the mastocytes degranulation (in a bigger number and with more connections with the nervous fibres in the eczematous and normal skin of atopic people), which induces the neurogenic inflammation.
Therefore, diagnosis must be confirmed by histopathologic studies, which allow visualizing the capsule of the fibrous connective tissue surrounding the granulomatous tissue and important cells such as lymphocytes, associated to plasma cells, neutrophils, histiocytes, an eventually mastocytes and eosinophils.
Review of the literature has suggested that serum tryptase may be considered as a new marker of the instability of atheromatous plaque with regard to the existence of mastocytes in heart tissue.
TLR5 recognizes bacterial flagellin and is expressed in different cell types, including monocytes, mastocytes, dendritic cells, and epithelial cells (8,9).