tolerance dose

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tolerance dose

The amount of radiation that may be received by an individual within a specified period with negligible results.
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A phase Ia study has also been carried out in California on 26 patients, to see how it responds to brain cancer, which has resulted in the discovery of a maximum tolerated dose - 30mg/kg.
"Consequently the recommended phase II dose of ETS2101 in patients with brain cancer is line with the maximum tolerated dose of 30 mg/kg determined in the UK trial.
1.8 mg OD Victoza[R] (liraglutide) or 10 microgram twice daily (BID) Byetta[R] (exenatide)) or documented maximum tolerated dose (i.e.
Secondary outcomes included maximum tolerated dose of study drug, short-form 3 6-item general health survey (SF-36), Beck depression inventory, and adverse events.
The primary objectives of the study are to determine the maximum tolerated dose and to explore the safety profile of a single dose of CRS-100 in adult patients with cancer that has metastasized to the liver.
Parathion (maximum tolerated dose, 0.1 mg/kg) was far more systemically toxic than was chlorpyrifos or diazinon (maximum tolerated dose, 1-5 mg/kg).
After a few studies in "healthies," you've come up with what you think is the maximum tolerated dose, and you now have some understanding about how quickly your drug is absorbed and eliminated in humans.
The toxicity of DEHP, as one example, is so low that test animals must ingest huge amounts to reach the maximum tolerated dose (MTD), which would equal 500 g/day for an adult.
While acknowledging that some animal tests, such as the Lethal Dose 50 Percent (LD50) and the Maximum Tolerated Dose (MTD), may yield results that are statistically invalid and difficult to extrapolate to humans, he nevertheless concludes, "Though imperfect, in most tests the mouse ramains the best model for man."
Researchers feed lab rats the "maximum tolerated dose" (MTD) of a substance and then see if tumors start growing in the animals.
The Company also announced that it has not determined a maximum tolerated dose and that it plans to continue the dose escalation portion of the study in parallel.
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