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Familial Mediterranean Fever (FMF), also known as Armenian disease or paroxysmal polyserositis is a hereditary inflammatory disease that is commonly inherited among people of Mediterranean origin.
The company obtained the use patent by doing some research on colchicine, which had already been well studied as a treatment for gout, familial Mediterranean fever, cirrhosis of the liver, and some other conditions.
Such an action would represent a significant and unnecessary safety hazard for patients with gout and familial Mediterranean fever.
The target genes were those causing hemoglobin disorders, glucose-ophosphate dehydrogenase deficiency, the receptor 1 for tumor necrosis factor-[alpha] (TNFRSFIA), responsible for tumor necrosis factor receptor-associated periodic syndrome (TRAPS; MIM 142680), and the MEFV gene, which is involved in familial Mediterranean fever (FMF; MIM 249100).
AutoGenomics, a leader in providing automated, molecular testing solutions, announced today that it has launched a new test for the identification of genetic mutations implicated in the development of Familial Mediterranean Fever (FMF).
22,23) Moreover, NLR and MPV had higher levels at the attack periods in familial Mediterranean fever patients.
Ilaris is the first and only FDA approved biologic treatment for Tumor Necrosis Factor-Receptor Associated Periodic Syndrome (TRAPS), Hyperimmunoglobulin D Syndrome (HIDS)/Mevalonate Kinase Deficiency (MKD) and Familial Mediterranean Fever (FMF).
M2 PHARMA-September 25, 2014-Sophia Genetics gets CE-IVD mark for genetic testing of Familial Mediterranean Fever, Hypercholesterolemia
The FDA approved the drug with exclusive marketing rights for gout for 3 years and for Familial Mediterranean Fever for 7 years; the longer exclusivity period for its use in Familial Mediterranean Fever is because that indication qualified it as an orphan drug.

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