BM aspiration was performed in 24 cases (43.6%), and megakaryocytes
were present in all cases.
For years, researchers tried to find chemicals that regulate the body's platelet-producing cells, called megakaryocytes
. They thought those chemicals caused megakaryocytes
to multiply, mature, and bud off platelets.
Further, haemophagocytic histiocytes were observed with a decrease in erythropoietic and granulopoietic cells, while megakaryocytes
were rarely observed (Figure).
Bone marrow cells were collected and performed the following examinations: (a) cytology showed marked hypercellular marrow with 2.5% myeloblasts, 4.5% promyelocyte, 31.5% myelocyte, 14.5% metamyelocytes, increased number of megakaryocytes
, and neutrophil alkaline phosphatase score at 30 (normal range 13–130); (b) cytogenetic analysis revealed 46, XY, t(9;22)(q34; q11.2) in 10 of 10 metaphase cells; (c) molecular analysis by quantitative polymerase chain reaction found P190 positive with negative results for P210 and P230.
Caption: FIGURE 4: Bone Marrow Core Biopsy: picture (intermediate magnification, H&E) shows a hypercellular bone marrow with increased number of dysplastic megakaryocytes
. Dysplastic features include nuclear hypolobation (a) and micromegakaryocytes (b).
Others showed that MMP-9 can influence the action of aspirin through modification of the [TXA.sub.2] pathway  and that aspirin can influence MMP-2 and MMP-9 production in monocytes  and megakaryocytes
Revolade is a once-daily oral thrombopoietin receptor agonist that works by inducing stimulation and differentiation of megakaryocytes
from bone marrow stem cells to increase platelet production.
(6) In TAR syndrome, significant laboratory findings include thrombocytopenia with normal platelet morphology in peripheral smear and hypomegakaryocytic thrombocytopenia with small, basophilic, vacuolated megakaryocytes
on bone marrow examination with normal or elevated plasma thrombopoietin levels.
 Estrogen receptor-[beta] (ER-[beta]) protein is present in glycoprotein IIb + ve megakaryocytes
Its de novo protein product contributes to cytoplasmic maturation in megakaryocytes
and organelle development in platelets, but functions as a negative regulator of megakaryocyte
VWF is synthesized and released from the endothelial cells and megakaryocytes
into the circulation (3).