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 (mĕg′ə-kăr′ē-ō-sīt′, -ə-sīt′)
A large cell of the bone marrow that has a lobulated nucleus and releases platelets into the bloodstream.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Physiology) an abnormally large bone marrow cell, with a lobulated nucleus, that produces platelets through the fragmentation of its cytoplasm
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˌmɛg əˈkær i əˌsaɪt)

a large bone marrow cell, with a lobed nucleus, whose cytoplasm is the source of blood platelets.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.megakaryocyte - a large bone marrow cellmegakaryocyte - a large bone marrow cell; regarded as the source of blood platelets
bone cell - a cell that is part of a bone
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
For years, researchers tried to find chemicals that regulate the body's platelet-producing cells, called megakaryocytes. They thought those chemicals caused megakaryocytes to multiply, mature, and bud off platelets.
Further, haemophagocytic histiocytes were observed with a decrease in erythropoietic and granulopoietic cells, while megakaryocytes were rarely observed (Figure).
Bone marrow cells were collected and performed the following examinations: (a) cytology showed marked hypercellular marrow with 2.5% myeloblasts, 4.5% promyelocyte, 31.5% myelocyte, 14.5% metamyelocytes, increased number of megakaryocytes, and neutrophil alkaline phosphatase score at 30 (normal range 13–130); (b) cytogenetic analysis revealed 46, XY, t(9;22)(q34; q11.2) in 10 of 10 metaphase cells; (c) molecular analysis by quantitative polymerase chain reaction found P190 positive with negative results for P210 and P230.
Caption: FIGURE 4: Bone Marrow Core Biopsy: picture (intermediate magnification, H&E) shows a hypercellular bone marrow with increased number of dysplastic megakaryocytes. Dysplastic features include nuclear hypolobation (a) and micromegakaryocytes (b).
Others showed that MMP-9 can influence the action of aspirin through modification of the [TXA.sub.2] pathway [23] and that aspirin can influence MMP-2 and MMP-9 production in monocytes [32] and megakaryocytes [33, 34].
Revolade is a once-daily oral thrombopoietin receptor agonist that works by inducing stimulation and differentiation of megakaryocytes from bone marrow stem cells to increase platelet production.
(6) In TAR syndrome, significant laboratory findings include thrombocytopenia with normal platelet morphology in peripheral smear and hypomegakaryocytic thrombocytopenia with small, basophilic, vacuolated megakaryocytes on bone marrow examination with normal or elevated plasma thrombopoietin levels.
[7] Estrogen receptor-[beta] (ER-[beta]) protein is present in glycoprotein IIb + ve megakaryocytes and platelets.
Its de novo protein product contributes to cytoplasmic maturation in megakaryocytes and organelle development in platelets, but functions as a negative regulator of megakaryocyte proliferation.
VWF is synthesized and released from the endothelial cells and megakaryocytes into the circulation (3).