macrencephaly

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macrencephaly

(ˌmækrənˈsɛfəlɪ) or less commonly

macrencephalia

n
(Pathology) the condition of having an abnormally large brain
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.macrencephaly - an abnormally large braincasemacrencephaly - an abnormally large braincase  
abnormalcy, abnormality - an abnormal physical condition resulting from defective genes or developmental deficiencies
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
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References in periodicals archive ?
Megalencephalic leukoencephalopathy (MLC) is an uncommon neurodegenerative disorder characterized by infantile-onset megalencephaly and cerebral leukoencephalopathy, particularly subcortical cysts in the anterior temporal area of the brain.
Megalencephaly and hemimegalencephaly: breakthroughs in molecular etiology.
Diffuse cortical malformations: agyria, pachygyria, polymicrogyria, microcephaly, megalencephaly, microdysgenesis.
For example, Alexander disease is a rare neurological disease with defect in myelination and it is known by seizure, developmental delay, intellectual disability, and spasticity, similar to PMD; however it has megalencephaly which is absent in PMD.
Muzny et al., "Whole exome sequencing identifies the first STRADA point mutation in a patient with polyhydramnios, megalencephaly, and symptomatic epilepsy syndrome (PMSE)," American Journal of Medical Genetics A, vol.
Conditions associated with unilateral megalencephaly, as in the linear nevus syndrome, should also be considered.
Dobyns, "Megalencephaly syndromes and activating mutations in the PI3K-AKT pathway: MPPH and MCAP," American Journal of Medical Genetics C: Seminars in Medical Genetics, vol.
Summary: TEHRAN (FNA)- A research team has discovered new gene mutations associated with markedly enlarged brain size, or megalencephaly.